| The incidence of myasthenia gravis: a systematic literature review. | |
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MedLine Citation:
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PMID: 20130418 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A systematic review of literature published between 1980 and 2007, on the incidence of myasthenia gravis, was undertaken. METHODS: All relevant papers found through searches of Medline, Embase and Science Direct were critically appraised and an assessment was made of the reliability of the reported incidence data. RESULTS: Thirty-one studies were included in the review, the majority of which investigated populations in Europe. The incidence rates reported were between 3.0 and 30.0/1,000,000/year. However, it is thought that the rates at the upper end of this range, reported by the prospective studies, provided the most accurate estimates. Overall, incidence rates have increased over time owing to a greater awareness of the disease and improved methods of diagnosis. CONCLUSIONS: The most accurate estimate of incidence of myasthenia gravis was around 30/ 1,000,000/year. The incidence in children and adolescents aged 0-19 years was found to be between 1.0 and 5.0/ 1,000,000/year. The rates presented in this review are likely to be an underestimate of the true incidence rates, as mild cases will have been missed and cases in the elderly will have been misdiagnosed. |
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Authors:
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Anita McGrogan; Samantha Sneddon; Corinne S de Vries |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-02-02 |
Journal Detail:
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Title: Neuroepidemiology Volume: 34 ISSN: 1423-0208 ISO Abbreviation: Neuroepidemiology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-04-16 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8218700 Medline TA: Neuroepidemiology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 171-83 Citation Subset: IM |
Copyright Information:
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Copyright 2010 S. Karger AG, Basel. |
Affiliation:
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Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. a.mcgrogan@bath.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Clinical Trials as Topic / methods Female Humans Incidence Male Myasthenia Gravis / diagnosis, epidemiology*, therapy Risk Factors Sex Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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