Document Detail

The incidence of myasthenia gravis: a systematic literature review.
MedLine Citation:
PMID:  20130418     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A systematic review of literature published between 1980 and 2007, on the incidence of myasthenia gravis, was undertaken.
METHODS: All relevant papers found through searches of Medline, Embase and Science Direct were critically appraised and an assessment was made of the reliability of the reported incidence data.
RESULTS: Thirty-one studies were included in the review, the majority of which investigated populations in Europe. The incidence rates reported were between 3.0 and 30.0/1,000,000/year. However, it is thought that the rates at the upper end of this range, reported by the prospective studies, provided the most accurate estimates. Overall, incidence rates have increased over time owing to a greater awareness of the disease and improved methods of diagnosis.
CONCLUSIONS: The most accurate estimate of incidence of myasthenia gravis was around 30/ 1,000,000/year. The incidence in children and adolescents aged 0-19 years was found to be between 1.0 and 5.0/ 1,000,000/year. The rates presented in this review are likely to be an underestimate of the true incidence rates, as mild cases will have been missed and cases in the elderly will have been misdiagnosed.
Anita McGrogan; Samantha Sneddon; Corinne S de Vries
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-02-02
Journal Detail:
Title:  Neuroepidemiology     Volume:  34     ISSN:  1423-0208     ISO Abbreviation:  Neuroepidemiology     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-16     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8218700     Medline TA:  Neuroepidemiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  171-83     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.
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MeSH Terms
Age Factors
Clinical Trials as Topic / methods
Myasthenia Gravis / diagnosis,  epidemiology*,  therapy
Risk Factors
Sex Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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