Document Detail

Incidence of late thromboembolic events after catheter ablation of atrial fibrillation.
MedLine Citation:
PMID:  21778595     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A low incidence of thromboembolic events after successful catheter ablation of atrial fibrillation (AF) during a mid-term follow-up period was recently reported. However, because the incidence of such events over the long term is unknown, we investigated the late incidence of thromboembolic events after catheter ablation.
METHODS AND RESULTS: Patients with paroxysmal and persistent AF undergoing catheter ablation and being followed up for at least 24 months formed the study group (n = 524); 82 patients (16%) had CHADS₂ scores of at least 2. Mean follow-up was 44 ± 13 months. Warfarin was discontinued in 400 (93%) of 429 patients (82% of 524 patients) without AF recurrence. None of the patients without AF recurrence suffered thromboembolic events, whereas 3 of 95 patients (3%) with AF recurrence did (P < 0.001). One of the 3 was a late AF recurrence occurring > 12 months after catheter ablation. There were 2 nonfatal major hemorrhagic events in patients with AF recurrence who continued on warfarin, but no hemorrhagic events were observed in patients free from AF (P = 0.002).
CONCLUSIONS: Maintenance of sinus rhythm after catheter ablation of AF was associated with a lower incidence of thromboembolic events during long-term follow-up >3 years. This result suggests that catheter ablation reduces thromboembolic events if patients continue anticoagulation regardless of the ablation outcome.
Atsuhiko Yagishita; Yoshihide Takahashi; Atsushi Takahashi; Akira Fujii; Shigeki Kusa; Tadashi Fujino; Toshihiro Nozato; Taishi Kuwahara; Kenzo Hirao; Mitsuaki Isobe
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Publication Detail:
Type:  Journal Article     Date:  2011-07-21
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  75     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-09-22     Completed Date:  2012-03-13     Revised Date:  2012-12-19    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2343-9     Citation Subset:  IM    
Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
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MeSH Terms
Aged, 80 and over
Anticoagulants / therapeutic use
Atrial Fibrillation / complications*,  surgery
Catheter Ablation*
Follow-Up Studies
Middle Aged
Thromboembolism / etiology*,  prevention & control
Warfarin / therapeutic use
Young Adult
Reg. No./Substance:
0/Anticoagulants; 81-81-2/Warfarin
Comment In:
Circ J. 2011;75(10):2312-3   [PMID:  21817808 ]

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