Document Detail


Incidence and electrophysiologic properties of dissociated pulmonary vein activity following pulmonary vein isolation during catheter ablation of atrial fibrillation.
MedLine Citation:
PMID:  20586827     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
INTRODUCTION: pulmonary veins (PV) play an important role in the arrhythmogenesis of atrial fibrillation (AF). Catheter-based PV isolation is one of the primary treatments for symptomatic drug refractory AF. Following electrical isolation, isolated rhythms in the PV are encountered. The aim of this study was to assess the frequency of postisolation PV activity and classify the different rhythms observed.
METHODS AND RESULTS: this single center prospective study sought to assess the dissociated activity in the PVs following their isolation during AF ablation. In 100 consecutive patients (60 paroxysmal, 40 persistent) undergoing AF ablation, dissociated PV activity was recorded using a multielectrode mapping catheter following antral PV isolation. The dissociated PV activity was classified as (1) silent, (2) isolated ectopic beats, (3) ectopic rhythm, and (4) PV fibrillation. All the PVs were successfully isolated in all the patients. In 91 of 100 patients, there was dissociated activity in at least 1 isolated ipsilateral PV group. There was no significant difference in spontaneous PV activity between patients with paroxysmal and persistent AF (91.7% vs 90%, P = 1.0). Among the 200 isolated ipsilateral PV groups, 64 of 200 (32%) were silent, 86 of 200 (43%) demonstrated isolated ectopic beats, 41 of 200 (20.5%) had ectopic rhythms and 9 of 200 (4.5%) had PV fibrillation. The average cycle length of the PV ectopic rhythm was 2594 ± 966 ms (range 1193-4750 ms).
CONCLUSIONS: following PV isolation, a majority of patients demonstrate dissociated activity in at least 1 PV. This finding was evident in patients with both paroxysmal and persistent AF.
Authors:
Rajesh Kabra; E Kevin Heist; Conor D Barrett; David Donaldson; Dan Blendea; Roy Beinart; Jacob Koruth; Sheldon Singh; Jeremy Ruskin; Moussa Mansour
Related Documents :
19209757 - Efficacy and safety of intraoperative radiofrequency ablation in management of hepatoce...
19875397 - The difference in autonomic denervation and its effect on atrial fibrillation recurrenc...
11220537 - Determinants of development of permanent atrial fibrillation and its treatment.
3369437 - Acute leukemia following treatment of polycythemia vera and essential thrombocythemia w...
8708907 - Current status of 21 patients who have survived more than 20 years since undergoing sur...
19341877 - Duplex ultrasound as the sole long-term surveillance method post-endovascular aneurysm ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  21     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1338-43     Citation Subset:  IM    
Affiliation:
Heart Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The P-selectin gene polymorphism Val168Met: a novel risk marker for the occurrence of primary ventri...
Next Document:  Clinical significance of early recurrences of atrial tachycardia after atrial fibrillation ablation.