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Incidence, Clinical Features, Laboratory Findings and Outcome of Multiple Myeloma Patients Presenting Extramedullary Relapse.
MedLine Citation:
PMID:  23151071     Owner:  NLM     Status:  Publisher    
ABSTRACT: Extramedullary plasmacytomas constitute a rare and not well studied subset of MM relapses. We report the incidence, clinical-laboratory features and outcome of patients with MM and extramedullary relapse (ExMeR). 303 symptomatic MM patients were recorded in a thirteen years period in two institutions. 28 cases of ExMeR (9%) were recorded. There was an increased frequency of elevated LDH (p=0.026), bone plasmacytomas (p=0.001) and fractures (p=0.002) at diagnosis, in ExMeR patients compared to the others. ExMeR was associated with an ominous outcome, high LDH, constitutional symptoms and a statistical significant decrease of monoclonal paraprotein compared to levels at diagnosis (p=0.009). Prior treatment with bortezomib was associated with a decreased hazard of ExMeR (p=0.041). Overall survival (OS) was decreased in ExMeR patients compared to the others (38 vs. 59 months, p=0.006). MM patients with ExMeR have a lower OS and their clinical and laboratory features differ from those without.
Xenofon Papanikolaou; Panagiotis Repousis; Tatiana Tzenou; Dimitris Maltezas; Maria Kotsopoulou; Katerina Megalakaki; Maria Angelopoulou; Elektra Dimitrakoloulou; Efstathios Koulieris; Vassiliki Bartzis; Gerasimos Pangalis; Panagiotis Panayotidis; Marie-Christine Kyrtsonis
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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