Document Detail

Incidence of cardiac arrhythmias in asymptomatic hereditary hemochromatosis subjects with C282Y homozygosity.
MedLine Citation:
PMID:  22196777     Owner:  NLM     Status:  MEDLINE    
It is not well known whether systemic iron overload per se in hereditary hemochromatosis (HH) is associated with cardiac arrhythmias before other signs and symptoms of cardiovascular disease occur. In the present study, we examined the incidence of cardiac arrhythmia in cardiac asymptomatic subjects with HH (New York Heart Association functional class I) and compared it to that in age- and gender-matched normal volunteers. The 42 subjects with HH and the 19 normal control subjects were recruited through the National Heart, Lung, and Blood Institute-sponsored "Heart Study of Hemochromatosis." They completed 48-hour Holter electrocardiography ambulatory monitoring at the baseline evaluation. The subjects with HH were classified as newly diagnosed (group A) and chronically treated (group B) subjects. All subjects with HH had C282Y homozygosity, and the normal volunteers lacked any HFE gene mutations known to cause HH. Although statistically insignificant, the incidence of ventricular and supraventricular ectopy tended to be greater in the combined HH groups than in the controls. Supraventricular ectopy was more frequently noted in group B compared to in the controls (ectopy rate per hour 11.1 ± 29.9 vs 1.5 ± 3.5, p < 0.05, using the Kruskal-Wallis test). No examples of heart block, other than first-degree atrioventricular node block, were seen in any of the subjects. The incidence of cardiac arrhythmias was not significantly reduced after 6 months of intensive iron removal therapy in the group A subjects. No life-threatening arrhythmias were observed in our subjects with HH. In conclusion, our data suggest that the incidence of cardiac arrhythmias is, at most, marginally increased in asymptomatic subjects with HH. A larger clinical study is warranted to further clarify our observation.
Yukitaka Shizukuda; Dorothy J Tripodi; Gloria Zalos; Charles D Bolan; Yu-Ying Yau; Susan F Leitman; Myron A Waclawiw; Douglas R Rosing
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Intramural     Date:  2011-12-22
Journal Detail:
Title:  The American journal of cardiology     Volume:  109     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-05     Completed Date:  2012-05-01     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  856-60     Citation Subset:  AIM; IM    
Copyright Information:
Published by Elsevier Inc.
Cardiopulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
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MeSH Terms
Arrhythmias, Cardiac / epidemiology*,  etiology,  physiopathology
DNA / genetics*
DNA Mutational Analysis
Electrocardiography, Ambulatory
Ferritins / blood
Follow-Up Studies
Hemochromatosis / blood,  complications*,  genetics
Histocompatibility Antigens Class I / blood,  genetics*
Iron / blood
Membrane Proteins / blood,  genetics*
Middle Aged
Retrospective Studies
Transferrin / metabolism
United States / epidemiology
Grant Support
Reg. No./Substance:
0/HFE protein, human; 0/Histocompatibility Antigens Class I; 0/Membrane Proteins; 0/Transferrin; 7439-89-6/Iron; 9007-49-2/DNA; 9007-73-2/Ferritins

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