| Incidence of adverse drug events and medication errors in Japan: the JADE study. | |
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MedLine Citation:
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PMID: 20872082 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The epidemiology of adverse drug events (ADEs) and medication errors has received little evaluation outside the U.S. and Europe, and extrapolating from these data might not be valid, especially regarding selecting and prioritizing solutions. OBJECTIVE: To assess the incidence and preventability of ADEs and medication errors in Japan. DESIGN: The Japan Adverse Drug Events (JADE) study was a prospective cohort study. PATIENTS: A cohort of 3,459 adults admitted to a stratified random sample of seven medical and eight surgical wards and three intensive care units in three tertiary care hospitals over 6 months. MAIN MEASURES: We measured ADE and medication error rates from daily reviews of charts, laboratories, incident reports, and prescription queries by on-site reviewers; presence of a signal was considered an incident. Two independent physicians reviewed incidents to determine whether they were ADEs or medication errors and to assess severity and preventability. KEY RESULTS: We identified 1,010 ADEs and 514 medication errors (incidence: 17.0 and 8.7 per 1,000 patient-days, respectively) during the study period. Among ADEs, 1.6%, 4.9% and 33% were fatal, life-threatening and serious, respectively. Among ADEs, 14% were preventable. The rate per admission was 29 per 100 admissions, higher than in U.S. studies because associated with of the long length of hospital stay in Japan (mean, 17 days). CONCLUSIONS: The epidemiology and nature of ADEs and medication errors in Japan were similar to other countries, although more frequent per admission. Solutions that worked in these countries might thus improve medication safety in Japan, as could shortening hospital length of stay. |
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Authors:
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Takeshi Morimoto; Mio Sakuma; Kunihiko Matsui; Nobuo Kuramoto; Jinichi Toshiro; Junji Murakami; Tsuguya Fukui; Mayuko Saito; Atsushi Hiraide; David W Bates |
Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-09-25 |
Journal Detail:
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Title: Journal of general internal medicine Volume: 26 ISSN: 1525-1497 ISO Abbreviation: J Gen Intern Med Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-12 Completed Date: 2011-11-10 Revised Date: 2012-02-01 |
Medline Journal Info:
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Nlm Unique ID: 8605834 Medline TA: J Gen Intern Med Country: United States |
Other Details:
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Languages: eng Pagination: 148-53 Citation Subset: IM |
Affiliation:
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Center for Medical Education, Kyoto University Graduate School of Medicine, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. morimoto@kuhp.kyoto-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cohort Studies Drug Toxicity / epidemiology* Female Hospitals / statistics & numerical data Humans Incidence Japan / epidemiology Male Medication Errors* / statistics & numerical data Middle Aged Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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