Document Detail

Inbred strain-specific effects of exercise in wild type and biglycan deficient mice.
MedLine Citation:
PMID:  20033775     Owner:  NLM     Status:  MEDLINE    
Biglycan (bgn)-deficient mice (KO) have defective osteoblasts which lead to changes in the amount and quality of bone. Altered tissue strength in C57BL6/129 (B6;129) KO mice, a property which is independent of tissue quantity, suggests that deficiencies in tissue quality are responsible. However, the response to bgn-deficiency is inbred strain-specific. Mechanical loading influences bone matrix quality in addition to any increase in bone mass or change in bone formation activity. Since many diseases influence the mechanical integrity of bone through altered tissue quality, loading may be a way to prevent and treat extracellular matrix deficiencies. C3H/He (C3H) mice consistently have a less vigorous response to mechanical loading vs. other inbred strains. It was therefore hypothesized that the bones from both wild type (WT) and KO B6;129 mice would be more responsive to exercise than the bones from C3H mice. To test these hypotheses at 11 weeks of age, following 21 consecutive days of exercise, we investigated cross-sectional geometry, mechanical properties, and tissue composition in the tibiae of male mice bred on B6;129 and C3H backgrounds. This study demonstrated inbred strain-specific compositional and mechanical changes following exercise in WT and KO mice, and showed evidence of genotype-specific changes in bone in response to loading in a gene disruption model. This study further shows that exercise can influence bone tissue composition and/or mechanical integrity without changes in bone geometry. Together, these data suggest that exercise may represent a possible means to alter tissue quality and mechanical deficiencies caused by many diseases of bone.
Joseph M Wallace; Kurtulus Golcuk; Michael D Morris; David H Kohn
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-12-24
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  38     ISSN:  1573-9686     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-30     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1607-17     Citation Subset:  IM    
Department of Biomedical Engineering, The University of Michigan, Ann Arbor, MI 48109-1078, USA.
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MeSH Terms
Compressive Strength / physiology
Elastic Modulus / physiology
Extracellular Matrix Proteins / genetics,  metabolism*
Mice, Inbred C57BL
Mice, Knockout
Motor Activity / physiology*
Physical Exertion / physiology*
Proteoglycans / genetics,  metabolism*
Stress, Mechanical
Tensile Strength / physiology
Tibia / cytology*,  physiology*
Grant Support
P30 AR046024-04/AR/NIAMS NIH HHS; P30-AR46024/AR/NIAMS NIH HHS; R01 AR050210/AR/NIAMS NIH HHS; R01 AR052010-03/AR/NIAMS NIH HHS; R90 DK071506-03/DK/NIDDK NIH HHS; R90-DK071506/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Bgn protein, mouse; 0/Biglycan; 0/Extracellular Matrix Proteins; 0/Proteoglycans

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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