Document Detail

Is the inattentive subtype of ADHD different from the combined/hyperactive subtype?
MedLine Citation:
PMID:  19767592     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the ADHD combined/hyperactive subtype (ADHD/CH) to the ADHD inattentive subtype (ADHD/I) on the level of comorbidity, treatment response, and possible etiological factors. METHOD: A total of 371 clinically referred children diagnosed with ADHD aged between 6 and 12 years are recruited for a double-blind, placebo-controlled trial of methylphenidate. Comorbidity, treatment response, and stress during pregnancy are assessed for each participant. Genotyping is done for the DAT, DRD4, and 5-HTT genes. Mothers report smoking or alcohol consumption during their pregnancy and their child's birth weight. RESULTS: The ADHD/CH children show both a higher frequency of conduct disorder and good response to treatment, are exposed to more moderate stress during their mothers' pregnancy, and show a higher frequency of L/L genotype for the 5-HTT-linked polymorphic region. CONCLUSION: The significant differences found between the ADHD/CH and the ADHD/I subtypes raise the possibility that the two may be separate disorders.
Natalie Grizenko; Michael Paci; Ridha Joober
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-18
Journal Detail:
Title:  Journal of attention disorders     Volume:  13     ISSN:  1557-1246     ISO Abbreviation:  J Atten Disord     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615686     Medline TA:  J Atten Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  649-57     Citation Subset:  IM    
McGill University.
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MeSH Terms
Attention Deficit Disorder with Hyperactivity / classification*,  diagnosis*,  genetics
Diagnosis, Differential
Grant Support
//Canadian Institutes of Health Research

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