| Inappropriate renin secretion and abnormal cardiovascular reflexes in coarctation of the aorta. | |
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MedLine Citation:
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PMID: 7020728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The response of the renin-angiotensin system to high and low sodium diets, to standing, and to saralasin infusion was assessed before and after surgical correction of aortic coarctation in a 27-year-old man. The cardiovascular responses to tests of autonomic function were measured. The heart rate responses to the Valsalva manoeuvre and standing were abnormal before operation, and plasma renin levels were high and renin secretion responded poorly to changes in dietary sodium, to standing, and to saralasin. Renin responsiveness and cardiovascular reflexes returned to normal after operation. The results are consistent with the hypothesis that there is a high level of sympathetic efferent activity in coarctation of the aorta and that factors other than increased activity of the renin-angiotensin system may cause high blood pressure. |
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Authors:
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D J Warren; R S Smith; R B Naik |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: British heart journal Volume: 45 ISSN: 0007-0769 ISO Abbreviation: Br Heart J Publication Date: 1981 Jun |
Date Detail:
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Created Date: 1981-10-25 Completed Date: 1981-10-25 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370634 Medline TA: Br Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 733-6 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aortic Coarctation / physiopathology*, surgery Autonomic Nervous System / physiopathology Blood Pressure Diet Heart Rate Hemodynamics* Humans Male Reflex / physiology Renin / secretion* Saralasin / diagnostic use Sodium / metabolism |
| Chemical | |
Reg. No./Substance:
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34273-10-4/Saralasin; 7440-23-5/Sodium; EC 3.4.23.15/Renin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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