Document Detail

Inappropriate antidiuretic state in long-term psychiatric inpatients.
MedLine Citation:
PMID:  2315814     Owner:  NLM     Status:  MEDLINE    
To investigate the occurrence of an inappropriate antidiuretic state in a long-term psychiatric inpatient population, 690 patients underwent serum sodium determination. Forty-four patients (6.4%) had levels less than 133 mmol/l. Fifteen of these patients could be investigated further and the biochemical findings in all were consistent with an inappropriate antidiuretic state. Evidence of previous episodes of water intoxication was found in 80% of these patients. Although more than one possible cause was present in most patients, the two factors most strongly incriminated in the pathogenesis of the inappropriate antidiuretic state were the drugs carbamazepine and hydrochlorothiazide.
R A Emsley; H van der Meer; C Aalbers; J J Taljaard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  77     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-23     Completed Date:  1990-04-23     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  307-8     Citation Subset:  IM    
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MeSH Terms
Carbamazepine / adverse effects*
Hydrochlorothiazide / adverse effects*
Hyponatremia / chemically induced*
Inappropriate ADH Syndrome / chemically induced*
Mental Disorders / drug therapy*
Middle Aged
Reg. No./Substance:
0J48LPH2TH/Hydrochlorothiazide; 33CM23913M/Carbamazepine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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