| Inadvertent recombinant human follicle stimulating hormone bolus instead of human chorionic gonadotrophin leads to the retrieval of competent oocytes in IVF program. | |
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MedLine Citation:
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PMID: 19732874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To present a case where recombinant human FSH (r-hFSH) was accidentally used instead of hCG and resulted in oocyte maturation. DESIGN: Case report. SETTING: A tertiary infertility center. PATIENT(S): A 36-year-old woman underwent IVF for infertility problems. The couple was unable to obtain a pregnancy during the previous 2 years. INTERVENTION(S): Oocyte retrieval after a r-hFSH bolus (two vials of Gonal-F 1050 IU) instead of the routinely used hCG. MAIN OUTCOME MEASURE(S): Oocyte maturity evaluation, fertilization after intracytoplasmic sperm injection, cleavage stage, and embryo quality. RESULT(S): A total of nine oocytes were retrieved; eight were metaphase II. Three eggs were fertilized by intracytoplasmic sperm injection, and four of the remaining MII oocytes were cryopreserved. All three oocytes fertilized and developed to three good-quality embryos that were transferred on day 2. No pregnancy was obtained from this fresh transfer cycle or from transferred embryos resulting from the thawing cycle. CONCLUSION(S): A massive r-hFSH administration can lead to the retrieval of mature MII oocytes that are able to fertilize and give good-quality embryos to transfer. |
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Authors:
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Veronica Bianchi; Luca Dal Prato; Andrea Maccolini; Silvia Mazzone; Andrea Borini |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-09-03 |
Journal Detail:
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Title: Fertility and sterility Volume: 92 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2009-11-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1747.e1-3 Citation Subset: IM |
Affiliation:
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Tecnobios Procreazione, Centre for Reproductive Health, Casa di Cura Città di Udine, Udine, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chorionic Gonadotropin / therapeutic use Drug Administration Routes Drug Administration Schedule Female Fertilization in Vitro / methods* Follicle Stimulating Hormone / administration & dosage, therapeutic use* Humans Infertility / drug therapy* Medication Errors* Oocyte Retrieval Oocytes / cytology, drug effects, physiology Ovulation Induction / methods* Pregnancy Recombinant Proteins / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Chorionic Gonadotropin; 0/Recombinant Proteins; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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