Document Detail

Inadvertent relaxation of the ductus arteriosus by pharmacologic agents that are commonly used in the neonatal period.
MedLine Citation:
PMID:  20494739     Owner:  NLM     Status:  MEDLINE    
Premature birth and disruption of the normal maturation process leave the immature ductus arteriosus unable to respond to postnatal cues for closure. Strategies that advocate conservative management of the patent ductus arteriosus (PDA) in premature infants are dependent on identification of the symptomatic PDA and understanding the risk factors that predispose to PDA. Exposure of premature infants to unintended vasodilatory stimuli may be one of the risk factors for PDA that is under recognized. In this article, we summarize the clinical factors that are associated with PDA and review commonly used neonatal drugs for their vasodilatory properties. Data demonstrating relaxation of the ductus arteriosus by gentamicin and other aminoglycoside antibiotics, by cimetidine and other H2 receptor antagonists, and by heparin are provided as examples of neonatal therapies that have unanticipated effects that may promote PDA.
Jeff Reese; Alex Veldman; Lisa Shah; Megan Vucovich; Robert B Cotton
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  34     ISSN:  1558-075X     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-24     Completed Date:  2010-08-31     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-30     Citation Subset:  IM    
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MeSH Terms
Cimetidine / adverse effects
Ductus Arteriosus / drug effects*,  physiopathology
Ductus Arteriosus, Patent / chemically induced*,  physiopathology
Gentamicins / adverse effects
Heparin / adverse effects
Histamine H2 Antagonists / adverse effects
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / chemically induced,  drug therapy*
Nitric Oxide / adverse effects
Prostaglandins / adverse effects
Risk Factors
Vasodilation / drug effects*
Vasodilator Agents / adverse effects
Grant Support
Reg. No./Substance:
0/Gentamicins; 0/Histamine H2 Antagonists; 0/Prostaglandins; 0/Vasodilator Agents; 31C4KY9ESH/Nitric Oxide; 80061L1WGD/Cimetidine; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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