Document Detail

Inadequate vitamin D status in pregnancy: evidence for supplementation.
MedLine Citation:
PMID:  22007763     Owner:  NLM     Status:  MEDLINE    
The role of vitamin D in maintaining a healthy pregnancy has seen emerging interest among clinicians and researchers in recent years. The functions of this hormone are widespread and complex, and during pregnancy and breastfeeding it facilitates crucial transfer of calcium from mother to child for skeletal development. Aside from the role of vitamin D in bone development and health, a myriad of other physiological actions are now known, and it is hypothesized that maternal deficiency may increase susceptibility to adverse pregnancy events during pregnancy such as pre-eclampsia. The role of vitamin D in pregnancy and breastfeeding is summarized and applied to the knowledge from studies associating vitamin D deficiency with a range of adverse pregnancy outcomes, including pre-eclampsia and childhood asthma. Current clinical guidelines for vitamin D supplementation in pregnancy are discussed in the context of the available evidence. The need for robust randomized controlled trials to address areas of existing uncertainty is highlighted.
Sarah Finer; Khalid S Khan; Graham A Hitman; Chris Griffiths; Adrian Martineau; Catherine Meads
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Publication Detail:
Type:  Journal Article     Date:  2011-12-20
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  91     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-19     Completed Date:  2012-03-22     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  159-63     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors Acta Obstetricia et Gynecologica Scandinavica© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.
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MeSH Terms
Dietary Supplements*
Practice Guidelines as Topic
Pregnancy Complications / drug therapy*,  metabolism
Vitamin D / metabolism,  therapeutic use*
Vitamin D Deficiency / complications,  drug therapy*,  metabolism
Vitamins / metabolism,  therapeutic use*
Grant Support
G0800441//Medical Research Council
Reg. No./Substance:
0/Vitamins; 1406-16-2/Vitamin D

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