Document Detail

Inadequate treatment of syphilis in pregnancy.
MedLine Citation:
PMID:  6507531     Owner:  NLM     Status:  MEDLINE    
Pregnant women with untreated syphilis have high rates of adverse pregnancy outcome. Early syphilis in pregnancy, if not treated, results in 40% loss either by spontaneous abortions, stillbirth, or perinatal death. Another 40% of such pregnancies result in an infant born with congenital syphilis. Only 20% of such pregnancies result in a normal infant. Currently recommended treatment of early syphilis in pregnant women uses a dosage of 2.4 million U of benzathine penicillin G. Because of the potentially disastrous effect syphilis has on pregnancy outcome, the occurrence of any treatment failure must be considered seriously. In this brief report we present clinical summaries of four pregnant women treated for syphilis who represent probable treatment failures.
L Mascola; R Pelosi; C E Alexander
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  150     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-15     Completed Date:  1985-01-15     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  945-7     Citation Subset:  AIM; IM    
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MeSH Terms
Fetal Death / etiology
Infant, Newborn
Infant, Premature, Diseases / diagnosis
Penicillin G / therapeutic use*
Penicillin G Benzathine / administration & dosage,  therapeutic use*
Pregnancy Complications / drug therapy*
Syphilis / drug therapy*
Syphilis Serodiagnosis
Syphilis, Congenital / diagnosis,  drug therapy
Syphilis, Latent / diagnosis,  drug therapy
Reg. No./Substance:
1538-09-6/Penicillin G Benzathine; 61-33-6/Penicillin G

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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