Document Detail

Inadequate iodine nutrition of pregnant women from Extremadura (Spain).
MedLine Citation:
PMID:  18644824     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the iodine nutrition of the pregnant women of the Spanish Autonomous Community Extremadura. There are approximately 10,000 births per year in Extremadura, which historically contains areas with endemic goiter (Las Hurdes). DESIGN: Population study in which a representative sample of pregnant women of the general population was analyzed, along with another sample of pregnant women from traditionally goitrogenic areas. With the collaboration of selected health centers, an additional sample of blood and urine was obtained within the primary health care pregnancy-monitoring program; these samples were sent to a single central laboratory. METHODS: Biochemistry: determination of iodine and creatinine in urine, and serum concentrations of thyroxine, free thyroxine, tri-iodothyronine, TSH, thyroglobulin, and two anti-thyroid antibodies. Each parameter was measured by means of a single specific RIA. RESULTS: Changes between the first trimester and later stages of pregnancy of all biochemical variables studied corresponded with those described for other European areas with a comparable iodine nutrition. Using the urinary iodine concentration value as an indicator of iodine ingestion, it was found that in the first trimester of pregnancy six out of ten women from Extremadura ingested less than the currently recommended amount (250 microg I/day), and approximately three out of ten of these women ingested less than half of this amount. CONCLUSIONS: It is imperative to implement in all Extremadura the generalized and controlled use of complements that contain 200-250 microg I/day throughout pregnancy and, if possible, before.
Javier Sánchez-Vega; Francisco Escobar del Rey; Humberto Fariñas-Seijas; Gabriella Morreale de Escobar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-21
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  159     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2008-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  439-45     Citation Subset:  IM    
CICAB, Clinical Research Center, Extremadura University Hospital and Medical School, 07071 Badajoz, Spain.
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MeSH Terms
Autoantibodies / blood
Creatinine / blood,  urine
Goiter, Endemic / diagnosis,  metabolism*
Iodine / administration & dosage,  blood*,  deficiency*,  urine
Nutrition Assessment*
Pregnancy Complications / diagnosis,  metabolism*
Pregnancy Trimester, First
Sodium Chloride, Dietary / administration & dosage
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Reg. No./Substance:
0/Autoantibodies; 0/Sodium Chloride, Dietary; 0/iodized salt; 60-27-5/Creatinine; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7553-56-2/Iodine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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