Document Detail

Inadequacy of cardiovascular risk factor management in chronic kidney transplantation - evidence from the FAVORIT study.
MedLine Citation:
PMID:  22775763     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Kidney transplant recipients (KTRs) have increased risk of cardiovascular disease (CVD). Our objective is to describe the prevalence of CVD risk factors applying standard criteria and use of CVD risk factor-lowering medications in contemporary KTRs.
METHODS: The Folic Acid for Vascular Outcome Reduction in Transplantation study enrolled and collected medication data on 4107 KTRs with elevated homocysteine and stable graft function an average of five yr post-transplant.
RESULTS: CVD risk factors were common (hypertension or use of blood pressure (BP) lowering medication in 92%, borderline or elevated low-density lipoprotein (LDL) or use of lipid-lowering agent in 66%, history of diabetes mellitus in 41%, and obesity in 38%); prevalent CVD was reported in 20% of study participants. National Kidney Foundation BP guidelines (BP <130/80 mmHg) were not met by 69% of participants. Uncontrolled hypertension (BP of 140/90 mmHg or higher) was present in 44% of those taking antihypertension medication; 18% of participants had borderline or elevated LDL, of which 60% were untreated, and 31% of the participants with prevalent CVD were not using an antiplatelet agent.
CONCLUSION: There is opportunity to improve treatment and control of traditional CVD risk factors in kidney transplant recipients.
Myra A Carpenter; Matthew R Weir; Deborah B Adey; Andrew A House; Andrew G Bostom; John W Kusek
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-07-09
Journal Detail:
Title:  Clinical transplantation     Volume:  26     ISSN:  1399-0012     ISO Abbreviation:  Clin Transplant     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-08-13     Completed Date:  2013-01-10     Revised Date:  2014-06-04    
Medline Journal Info:
Nlm Unique ID:  8710240     Medline TA:  Clin Transplant     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  E438-46     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons A/S.
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MeSH Terms
Cardiovascular Diseases / etiology*
Chronic Disease
Disease Management
Double-Blind Method
Follow-Up Studies
Graft Rejection / etiology*
Hypertension / etiology*
Kidney Transplantation / adverse effects*
Middle Aged
Risk Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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