| Inactivity and inflammation in the critically ill patient. | |
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MedLine Citation:
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PMID: 17307114 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bed rest is a commonly prescribed activity restriction among patients in the ICU. Although bed rest may promote rest, recovery and safety, inactivity related to bed rest also may lead to complications and adverse outcomes. The biological mechanisms that lead to immediate and long-term sequelae from bed rest have not been elucidated. It may be the inflammatory factors common to critical illness combined with bed rest lead to a positive feedback loop, contributing to inflammatory disequilibrium. This disequilibrium has a profound affect on muscles. Muscle decay has serious and long-term adverse outcomes on survivors of critical illness. Mobility therapy may improve inflammatory disequilibrium and preserve muscles, leading to improved functional outcome. Investigations in the laboratory, in healthy people and among patients with systemic inflammatory disease, suggest that activity does not exacerbate inflammation. Clinically, exercise is beneficial to patients with various chronic inflammatory diseases. Further study is needed to best understand the role, duration, and frequency of activity in promoting recovery for critically ill patients. |
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Authors:
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Chris Winkelman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Critical care clinics Volume: 23 ISSN: 0749-0704 ISO Abbreviation: Crit Care Clin Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-02-19 Completed Date: 2007-04-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8507720 Medline TA: Crit Care Clin Country: United States |
Other Details:
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Languages: eng Pagination: 21-34 Citation Subset: IM |
Affiliation:
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Frances Payne Bolton School of Nursing, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. chris.winkelman@case.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bed Rest Cardiovascular Deconditioning / physiology Critical Illness* / rehabilitation Cytokines / physiology Humans Immobilization / adverse effects Inflammation / physiopathology* Intensive Care Units Interleukins / physiology Muscle, Skeletal / physiopathology Nitric Oxide / physiology Oxidative Stress / physiology Pulmonary Disease, Chronic Obstructive / physiopathology Reactive Oxygen Species / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Interleukins; 0/Reactive Oxygen Species; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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