Document Detail


Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides.
MedLine Citation:
PMID:  8030974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human milk was found to become antiviral during storage at 4 degrees C because of the release of fatty acids by lipolysis. The stored milk caused more than a 10,000-fold inactivation of visna virus during incubation at 37 degrees C for 30 minutes. Medium-chain saturated and long-chain unsaturated fatty acids inactivated visna virus and other enveloped viruses causing more than a 3000-fold to 10,000-fold reduction in virus titer. 1-Monoglycerides and ethers of medium-chain fatty acids were more antiviral than the corresponding free fatty acids. Antiviral fatty acids were found to affect the viral envelope, causing leakage and, at higher concentrations, a complete disintegration of the envelope and the viral particles. Lipids commonly found in natural products could possibly be used as antiviral agents against enveloped viruses.
Authors:
H Thormar; C E Isaacs; K S Kim; H R Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  724     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-08-09     Completed Date:  1994-08-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  465-71     Citation Subset:  IM    
Affiliation:
Institute of Biology, University of Iceland, Grensavegi, Reykjavík.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiviral Agents / pharmacology*
Cells, Cultured
Ethers
Fatty Acids, Nonesterified / pharmacology*
Glycerides / pharmacology*
Hydrolysis
Milk, Human / chemistry
Sheep
Viral Envelope Proteins / metabolism
Visna-maedi virus / drug effects*
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Ethers; 0/Fatty Acids, Nonesterified; 0/Glycerides; 0/Viral Envelope Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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