Document Detail


Inactivation of sarin and soman by cyclodextrins in vitro.
MedLine Citation:
PMID:  3569488     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cyclodextrins catalyzed the inactivation of sarin and soman but did not inactivate tabun and VX. Furthermore, sarin and soman showed greater affinity for beta-cyclodextrin than for alpha- or gamma-cyclodextrins. Thus beta-cyclodextrin appears to be an attractive starting material for the preparation of a catalyst able to inactivate sarin and soman more effectively. Such a catalyst might contribute to improving the therapy of poisoning caused by these two nerve agents.
Authors:
B Désiré; S Saint-André
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Experientia     Volume:  43     ISSN:  0014-4754     ISO Abbreviation:  Experientia     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-06-01     Completed Date:  1987-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376547     Medline TA:  Experientia     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  395-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Cyclodextrins / pharmacology*
Dextrins / pharmacology*
Kinetics
Organophosphorus Compounds / antagonists & inhibitors*
Organothiophosphorus Compounds / antagonists & inhibitors
Phosphoric Acid Esters / antagonists & inhibitors
Sarin / antagonists & inhibitors*
Soman / antagonists & inhibitors*
Starch / pharmacology*
alpha-Cyclodextrins*
beta-Cyclodextrins*
gamma-Cyclodextrins*
Chemical
Reg. No./Substance:
0/Cyclodextrins; 0/Dextrins; 0/Organophosphorus Compounds; 0/Organothiophosphorus Compounds; 0/Phosphoric Acid Esters; 0/alpha-Cyclodextrins; 0/beta-Cyclodextrins; 0/gamma-Cyclodextrins; 10016-20-3/alpha-cyclodextrin; 107-44-8/Sarin; 17465-86-0/gamma-cyclodextrin; 50782-69-9/VX; 7585-39-9/betadex; 77-81-6/tabun; 9005-25-8/Starch; 96-64-0/Soman

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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