Document Detail

Inactivation of potent pyrolysate mutagens by chlorinated tap water.
MedLine Citation:
PMID:  6337319     Owner:  NLM     Status:  MEDLINE    
The potent mutagens 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2, 62450-07-1), 2-amino-6-methyldipyrido-[1,2-a:3', 2'-d]imidazole (Glu-P-1, 67730-11-4) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ, 76180-96-6), isolated from pyrolysates of tryptophan and glutamic acid and from broiled sardines, respectively, were effectively degraded by chlorinated tap water with a concomitant loss of mutagenicity toward Salmonella typhimurium TA98 and TA100. The half-life of 10 microM IQ in the presence of 1.5 ppm of residual chlorine was less than 10 sec; those of Glu-P-1 and Trp-P-2 were 0.5-1 and 2-3 min, respectively. This means that a glass of chlorinated tap water (150 ml) containing 1.5 ppm of residual chlorine can break down about 200 micrograms of these pyrolysate mutagens within a couple of minutes.
M Tsuda; K Wakabayashi; T Hirayama; T Kawachi; T Sugimura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mutation research     Volume:  119     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-03-24     Completed Date:  1983-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  27-34     Citation Subset:  IM    
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MeSH Terms
Carbolines / antagonists & inhibitors
Cell Survival / drug effects
Chlorine / pharmacology*
Hot Temperature
Imidazoles / antagonists & inhibitors
Mutagenicity Tests
Mutagens / antagonists & inhibitors*
Quinolines / antagonists & inhibitors
Salmonella typhimurium / genetics
Spectrophotometry, Ultraviolet
Water Supply* / analysis
Reg. No./Substance:
0/Carbolines; 0/Imidazoles; 0/Mutagens; 0/Quinolines; 62450-07-1/Trp-P-2; 67730-11-4/2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole; 76180-96-6/2-amino-3-methylimidazo(4,5-f)quinoline; 7782-50-5/Chlorine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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