| Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated (3)He-, (12)C- and (20)Ne-ion beams. | |
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MedLine Citation:
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PMID: 11025645 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The LET-RBE spectra for cell killing for cultured mammalian cells exposed to accelerated heavy ions were investigated to design a spread-out Bragg peak beam for cancer therapy at HIMAC, National Institute of Radiological Sciences, Chiba, prior to clinical trials. Cells that originated from a human salivary gland tumor (HSG cells) as well as V79 and T1 cells were exposed to (3)He-, (12)C- and (20)Ne-ion beams with an LET ranging from approximately 20-600 keV/micrometer under both aerobic and hypoxic conditions. Cell survival curves were fitted by equations from the linear-quadratic model and the target model to obtain survival parameters. RBE, OER, alpha and D(0) were analyzed as a function of LET. The RBE increased with LET, reaching a maximum at around 200 keV/micrometer, then decreased with a further increase in LET. Clear splits of the LET-RBE or -OER spectra were found among ion species and/or cell lines. At a given LET, the RBE value for (3)He ions was higher than that for the other ions. The position of the maximum RBE shifts to higher LET values for heavier ions. The OER value was 3 for X rays but started to decrease at an LET of around 50 keV/micrometer, passed below 2 at around 100 keV/micrometer, and then reached a minimum above 300 keV/micrometer, but the values remained greater than 1. The OER was significantly lower for (3)He ions than the others. |
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Authors:
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Y Furusawa; K Fukutsu; M Aoki; H Itsukaichi; K Eguchi-Kasai; H Ohara; F Yatagai; T Kanai; K Ando |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiation research Volume: 154 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-11-28 Completed Date: 2001-01-25 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 485-96 Citation Subset: IM; S |
Affiliation:
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International Space Radiation Laboratory, Division of Radiotoxocology and Protection, Chiba, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acceleration Aerobiosis Animals Carbon Cell Hypoxia / radiation effects Cell Survival / radiation effects* Cricetinae Cricetulus Dose-Response Relationship, Radiation Helium Humans Isotopes Neon Oxygen / metabolism* Particle Accelerators Radiation, Ionizing Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Isotopes; 7440-01-9/Neon; 7440-44-0/Carbon; 7440-59-7/Helium; 7782-44-7/Oxygen |
| Comments/Corrections | |
Erratum In:
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Radiat Res. 2012 Jan;177(1):129-31 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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