| Inactivation of Crotalus atrox venom hemorrhagic activity by direct current exposure using hens' egg assay. | |
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MedLine Citation:
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PMID: 21800403 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The hemotoxic venoms of Viperidae and Crotalidae are responsible for most of the evenomations in the United States, West Africa, India, South-East Asia, New Guinea, and Latin America. We previously reported that a short exposure of Crotalus atrox venom to direct electric current (dc) from a low-voltage generator, in solution, causes consistent and irreversible inactivation of venom phospholipase A(2) and metalloproteases. Here we report by in vivo assay on chicken embryos at stage 18 of development according to Hamburger and Hamilton that the hemorrhagic activity of C. atrox venom is lost after exposure to dc (from low voltage). Venom was exposed to dc ranging between 0 and 1 mA. dc values above 0.7 mA abolished hemorrhage. Such in vivo data, showing that dc neutralizes C. atrox venom hemorrhagic activity suggest that a deeper knowledge is needed to understand the relationship among dc and biological matter. © 2011 Wiley Periodicals, Inc. J Biochem Mol Toxicol 00:1-5 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/jbt.20404. |
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Authors:
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Daniela Calzia; Silvia Ravera; Maria Grazia Aluigi; Carla Falugi; Alessandro Morelli; Isabella Panfoli |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-28 |
Journal Detail:
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Title: Journal of biochemical and molecular toxicology Volume: - ISSN: 1099-0461 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9717231 Medline TA: J Biochem Mol Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Biology, Università di Genova, Viale Benedetto XV 3, 16132 Genova, Italy. dcalzia@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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