Document Detail

Inactivated poliovaccine: adverse reactions and antibody responses.
MedLine Citation:
PMID:  6246709     Owner:  NLM     Status:  MEDLINE    
Adverse reactions and antbody responses after inactivated poliovaccine were studied in 380 children. Fever reaction (greater than or equal to 37.5 degree C rectally) was recorded in 14% of children after the first poliovirus vaccination and in 19% after the second. Restlessness was reported in 15% and 14% of the chidren. Fever reaction exceeding 38.5 degree C was seen in 5% of the vaccines. Before the first vaccination at the age of six month 29% of the 48 children had antibodies against poliovirus type 1 and 2 and 43% against type 3. The first vaccination induced no significant changes in antibody titers. After the second vaccination antibody responses were low and 35%, 9%, and 35% remained seronegative to types 1, 2 and 3, respectively. After the third vaccination at the age of two years the respective geometric mean titers were 1:67, 1:335 and 1:48. No measurable antibodies were found to type 1 in 23%, to type 2 in 2%, and to type 3 in 10%. Only one child was triplenegative. All seronegative children were revaccinated and in all vaccinees a seroconversion ocurred two weeks after the booster dose. The combination of inactivated poliovaccine to DPT (Diphtheria, Tetanus, Pertussis) vaccine induced no significant change in poliovirus antibodies or in adverse reactions.
O Ruuskanen; T T Salmi; M Stenvik; K Lapinleimu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica Scandinavica     Volume:  69     ISSN:  0001-656X     ISO Abbreviation:  Acta Paediatr Scand     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-07-28     Completed Date:  1980-07-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0000211     Medline TA:  Acta Paediatr Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  397-401     Citation Subset:  IM    
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MeSH Terms
Antibodies, Viral / analysis,  biosynthesis*
Child, Preschool
Diphtheria Toxoid / adverse effects
Fever / etiology
Pertussis Vaccine / adverse effects
Poliovirus / immunology
Poliovirus Vaccine, Inactivated / adverse effects*
Psychomotor Agitation
Tetanus Toxoid / adverse effects
Reg. No./Substance:
0/Antibodies, Viral; 0/Diphtheria Toxoid; 0/Pertussis Vaccine; 0/Poliovirus Vaccine, Inactivated; 0/Tetanus Toxoid

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