| Inactivated poliovaccine: adverse reactions and antibody responses. | |
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MedLine Citation:
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PMID: 6246709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adverse reactions and antbody responses after inactivated poliovaccine were studied in 380 children. Fever reaction (greater than or equal to 37.5 degree C rectally) was recorded in 14% of children after the first poliovirus vaccination and in 19% after the second. Restlessness was reported in 15% and 14% of the chidren. Fever reaction exceeding 38.5 degree C was seen in 5% of the vaccines. Before the first vaccination at the age of six month 29% of the 48 children had antibodies against poliovirus type 1 and 2 and 43% against type 3. The first vaccination induced no significant changes in antibody titers. After the second vaccination antibody responses were low and 35%, 9%, and 35% remained seronegative to types 1, 2 and 3, respectively. After the third vaccination at the age of two years the respective geometric mean titers were 1:67, 1:335 and 1:48. No measurable antibodies were found to type 1 in 23%, to type 2 in 2%, and to type 3 in 10%. Only one child was triplenegative. All seronegative children were revaccinated and in all vaccinees a seroconversion ocurred two weeks after the booster dose. The combination of inactivated poliovaccine to DPT (Diphtheria, Tetanus, Pertussis) vaccine induced no significant change in poliovirus antibodies or in adverse reactions. |
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Authors:
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O Ruuskanen; T T Salmi; M Stenvik; K Lapinleimu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica Scandinavica Volume: 69 ISSN: 0001-656X ISO Abbreviation: Acta Paediatr Scand Publication Date: 1980 May |
Date Detail:
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Created Date: 1980-07-28 Completed Date: 1980-07-28 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0000211 Medline TA: Acta Paediatr Scand Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 397-401 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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analysis,
biosynthesis* Child, Preschool Diphtheria Toxoid / adverse effects Fever / etiology Humans Pertussis Vaccine / adverse effects Poliovirus / immunology Poliovirus Vaccine, Inactivated / adverse effects* Psychomotor Agitation Tetanus Toxoid / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Diphtheria Toxoid; 0/Pertussis Vaccine; 0/Poliovirus Vaccine, Inactivated; 0/Tetanus Toxoid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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