| Inaccuracy of noninvasive estimates of VD/VT in clinical exercise testing. | |
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MedLine Citation:
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PMID: 7956406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the accuracy of noninvasive estimates of VD/VT in clinical exercise testing, we compared measurements of standard VD/VT with estimates based either on end-tidal CO2 (VD/VTET) or a published estimate of arterial PCO2 (VD/VTest) at peak exercise in 68 patients. Using regression analysis, we identified highly significant differences (p < 0.001) between each method and VD/VTstand across a broad range of observed VD/VT. Assuming a normal exercise VD/VT < or = 0.30, estimate methods were specific but were insensitive (50 percent for VD/VTET and 57 percent for VD/VTest) for identifying patients with abnormal gas exchange during exercise. Separate analysis of subgroups based on resting pulmonary function did not identify any group for which either method was acceptable. Our analysis showed that errors in estimating PaCO2, which are amplified by the Bohr equation when calculating VD/VT, are responsible for the inaccuracies of each noninvasive method. We conclude that noninvasive estimates of PaCO2 cannot replace measured arterial PCO2 for calculation of VD/VT during exercise. |
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Authors:
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D A Lewis; K E Sietsema; R Casaburi; D Y Sue |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chest Volume: 106 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-09 Completed Date: 1994-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1476-80 Citation Subset: AIM; IM |
Affiliation:
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Division of Respiratory and Critical Care Physiology and Medicine, Harbor-UCLA Medical Center, Torrance 90509. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Exercise Test* / instrumentation, methods, statistics & numerical data Exercise Tolerance Female Humans Linear Models Male Middle Aged Partial Pressure Pulmonary Gas Exchange Reproducibility of Results Respiratory Dead Space Respiratory Mechanics* Sensitivity and Specificity Tidal Volume |
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