Document Detail

Inability to attain oral anticoagulation: warfarin-rifampin interaction revisited.
MedLine Citation:
PMID:  8969357     Owner:  NLM     Status:  MEDLINE    
The warfarin-rifampin interaction is a well-described but underappreciated drug interaction. A case is reported in which therapeutic anticoagulation could not be achieved after nearly 4 weeks of warfarin therapy because of simultaneous administration of rifampin. This patient had the highest warfarin clearance ever reported in the literature. The world's literature describing warfarin-rifampin interactions for the past 32 years was reviewed to suggest guidelines for warfarin dosage when rifampin is given simultaneously.
P R Casner
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Southern medical journal     Volume:  89     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1996 Dec 
Date Detail:
Created Date:  1997-01-15     Completed Date:  1997-01-15     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1200-3     Citation Subset:  AIM; IM    
Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso 79905, USA.
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MeSH Terms
Antibiotics, Antitubercular / pharmacology*
Anticoagulants / pharmacokinetics*
Drug Interactions
Rifampin / pharmacology*
Warfarin / pharmacokinetics*
Reg. No./Substance:
0/Antibiotics, Antitubercular; 0/Anticoagulants; 13292-46-1/Rifampin; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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