| Inability of rhTSH to predict the evolution from subclinical hypothyroidism to overt disease. A pilot study. | |
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MedLine Citation:
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PMID: 21521938 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background: The use of recombinant human TSH is indicated to evaluate thyroid carcinoma patients. In recent years, some authors have reported that rhTSH could serve as a dynamic test of thyroid reserve. The aim of the present study was to determine whether or not rhTSH can predict the evolution from subclinical hypothyroidism (SH) to overt hypothyroidism. Materials and Methods: Twenty-one women who met the diagnostic criteria of SH were enrolled. All patients received a single dose of rhTSH (0.1 mg). Basal blood samples for TSH, free T4 (fT4), Tg, and anti-thyoperoxidase and anti-thyroglobulin antibodies were obtained before and 1 day after rhTSH administration. All patients were followed for 2 years, and blood samples were obtained every 6 months. Results: Twenty-four hours after rhTSH administration, the TSH level increased to > 20 mU/l in 14 patients; the serum peak TSH levels remained < 10 mU/l in only 5 patients. On follow-up, 7 women (33 %) required L-thyroxine replacement therapy for overt hypothyroidism or a persistent TSH level > 10 mlU/L. None of the parameters analyzed differed significantly between patients who developed overt hypothyroidism from those who had persistent SH. Conclusions: The response of thyroid function tests to a single low dose of rhTSH is not useful in identifying those patients with SH who will develop overt hypothyroidism over a 2-year period. |
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Authors:
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C Zafon; B Rodríguez; J B Montoro; D Cabo; J Mesa |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-26 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Dept. of Endocrinology, Hospital General Universitari Vall d'Hebron. Barcelona. Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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