Document Detail

Inability of gentamicin and fosfomycin to eliminate intracellular Enterobacteriaceae.
MedLine Citation:
PMID:  4030534     Owner:  NLM     Status:  MEDLINE    
The ability of gentamicin and fosfomycin to kill Salmonella typhimurium and Escherichia coli in a HeLa cell culture system was investigated. Antibiotic activity against extracellular, cell membrane-attached and intracellular bacteria were determined. Both gentamicin and fosfomycin had the same low ability to kill intracellular bacteria. The efficacy of fosfomycin against extracellular bacteria was also low, whereas gentamicin rapidly killed such bacteria. These observations show that intracellular enterobacteria are protected from the bactericidal activity of gentamicin and fosfomycin.
E Kihlström; L Andåker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antimicrobial chemotherapy     Volume:  15     ISSN:  0305-7453     ISO Abbreviation:  J. Antimicrob. Chemother.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-10-01     Completed Date:  1985-10-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7513617     Medline TA:  J Antimicrob Chemother     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  723-8     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Enterobacteriaceae / drug effects*
Fosfomycin / pharmacology*
Gentamicins / pharmacology*
Hela Cells
Microbial Sensitivity Tests
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Gentamicins; 23155-02-4/Fosfomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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