Document Detail

Inability of chronic alcoholics with liver disease to use food as a source of folates, thiamin and vitamin B6.
MedLine Citation:
PMID:  802999     Owner:  NLM     Status:  MEDLINE    
Absorption of folates, thiamin, vitamin B6, pantothenate and riboflavin from a natural food source--yeast--and their respective synthetic forms was studied in 37 patients with liver disease due to alcoholism, and 12 healthy, nonalcoholic subjects. All alcoholics absorbed riboflavin and pantothenate but had a significantly lowered absorption of thiamin and vitamin B6 from yeast. Alcoholics absorbed synthetic vitamin B6, but not thiamin. Ingested folylpolyglutamates (the predominant folates in yeast) could not serve as a source of folate for the alcoholics, but synthetic folylmonoglutamate served. We suggest that the folate, vitamin B6, and thiamin deficits so common in alcoholic liver disease ensue from inability to absorb these specific vitamins from foods.
H Baker; O Frank; R K Zetterman; K S Rajan; W ten Hove; C M Leevy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  28     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1975 Dec 
Date Detail:
Created Date:  1990-01-17     Completed Date:  1990-01-17     Revised Date:  2006-04-13    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1377-80     Citation Subset:  AIM; IM    
Department of Medicine, New Jersey Medical School, East Orange 07018.
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MeSH Terms
Folic Acid / pharmacokinetics
Folic Acid Deficiency / etiology
Intestinal Absorption
Liver Diseases, Alcoholic / complications,  metabolism*
Middle Aged
Pyridoxine / pharmacokinetics
Thiamine / pharmacokinetics
Vitamins / administration & dosage,  pharmacokinetics*
Yeast, Dried
Reg. No./Substance:
0/Vitamins; 59-30-3/Folic Acid; 59-43-8/Thiamine; 65-23-6/Pyridoxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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