| In vivo 1H NMR spectroscopy of the human brain at 9.4 T: initial results. | |
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MedLine Citation:
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PMID: 20598925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vivo proton NMR spectroscopy allows non-invasive detection and quantification of a wide range of biochemical compounds in the brain. Higher field strength is generally considered advantageous for spectroscopy due to increased signal-to-noise and increased spectral dispersion. So far (1)H NMR spectra have been reported in the human brain up to 7 T. In this study we show that excellent quality short echo time STEAM and LASER (1)H NMR spectra can be measured in the human brain at 9.4 T. The information content of the human brain spectra appears very similar to that measured in the past decade in rodent brains at the same field strength, in spite of broader linewidth in human brain. Compared to lower fields, the T(1) relaxation times of metabolites were slightly longer while T(2) relaxation values of metabolites were shorter (<100 ms) at 9.4 T. The linewidth of the total creatine (tCr) resonance at 3.03 ppm increased linearly with magnetic field (1.35 Hz/T from 1.5 T to 9.4 T), with a minimum achievable tCr linewidth of around 12.5 Hz at 9.4 T. At very high field, B(0) microsusceptibility effects are the main contributor to the minimum achievable linewidth. |
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Authors:
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Dinesh Kumar Deelchand; Pierre-François Van de Moortele; Gregor Adriany; Isabelle Iltis; Peter Andersen; John P Strupp; J Thomas Vaughan; Kâmil Uğurbil; Pierre-Gilles Henry |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-06-10 |
Journal Detail:
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Title: Journal of magnetic resonance (San Diego, Calif. : 1997) Volume: 206 ISSN: 1096-0856 ISO Abbreviation: J. Magn. Reson. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2010-12-08 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 9707935 Medline TA: J Magn Reson Country: United States |
Other Details:
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Languages: eng Pagination: 74-80 Citation Subset: IM |
Copyright Information:
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(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. dinesh@cmrr.umn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Brain Chemistry* Creatine / analysis Electromagnetic Fields Humans Magnetic Resonance Spectroscopy / instrumentation, methods* Middle Aged Occipital Lobe / chemistry Rats Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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P30 NS057091-04/NS/NINDS NIH HHS; P30NS057091/NS/NINDS NIH HHS; P41 RR008079-19/RR/NCRR NIH HHS; P41RR008079/RR/NCRR NIH HHS; R01 EB006835-03/EB/NIBIB NIH HHS; R01 NS038672-10/NS/NINDS NIH HHS; R01 NS038672-12/NS/NINDS NIH HHS; R01EB006835/EB/NIBIB NIH HHS; R01NS038672/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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57-00-1/Creatine |
| Comments/Corrections | |
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