Document Detail


In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy.
MedLine Citation:
PMID:  18997265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Structural changes in water molecules are related to physiological, anatomical and pathological properties of tissues. Near infrared (NIR) optical absorption methods are sensitive to water; however, detailed characterization of water in thick tissues is difficult to achieve because subtle spectral shifts can be obscured by multiple light scattering. In the NIR, a water absorption peak is observed around 975 nm. The precise NIR peak's shape and position are highly sensitive to water molecular disposition. We introduce a bound water index (BWI) that quantifies shifts observed in tissue water absorption spectra measured by broadband diffuse optical spectroscopy (DOS). DOS quantitatively measures light absorption and scattering spectra and therefore reveals bound water spectral shifts. BWI as a water state index was validated by comparing broadband DOS to magnetic resonance spectroscopy, diffusion-weighted MRI and conductivity in bound water tissue phantoms. Non-invasive DOS measurements of malignant and normal breast tissues performed in 18 subjects showed a significantly higher fraction of free water in malignant tissues (p < 0.0001) compared to normal tissues. BWI of breast cancer tissues inversely correlated with Nottingham-Bloom-Richardson histopathology scores. These results highlight broadband DOS sensitivity to molecular disposition of water and demonstrate the potential of BWI as a non-invasive in vivo index that correlates with tissue pathology.
Authors:
S H Chung; A E Cerussi; C Klifa; H M Baek; O Birgul; G Gulsen; S I Merritt; D Hsiang; B J Tromberg
Related Documents :
24849025 - Picoeukaryotic diversity and distribution in the subtropical-tropical south china sea.
22222275 - Regulation of nutrient intake in nectar-feeding birds: insights from the geometric fram...
677945 - Distribution and elimination of naphthalene and 2-methylnaphthalene in rainbow trout du...
7280305 - A quantitative approach to the marsupial brain in an eco-ethological perspective.
16108695 - A protein molecule in an aqueous mixed solvent: fluctuation theory outlook.
25026625 - Effectiveness of an antimicrobial polymer to decrease contamination of environmental su...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-11-07
Journal Detail:
Title:  Physics in medicine and biology     Volume:  53     ISSN:  0031-9155     ISO Abbreviation:  Phys Med Biol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-12     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6713-27     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Absorption
Adult
Aged
Body Water / chemistry*
Breast / chemistry
Breast Neoplasms / chemistry*,  pathology
Diffusion Magnetic Resonance Imaging
Female
Humans
Magnetic Resonance Spectroscopy
Middle Aged
Phantoms, Imaging
Spectrum Analysis / methods*
Grant Support
ID/Acronym/Agency:
P30 CA062203/CA/NCI NIH HHS; P30-CA62203/CA/NCI NIH HHS; P41 RR001192/RR/NCRR NIH HHS; P41 RR001192-29/RR/NCRR NIH HHS; P41-RR01192/RR/NCRR NIH HHS; R33 CA120175/CA/NCI NIH HHS; R33 CA120175-04/CA/NCI NIH HHS; U54 CA105480/CA/NCI NIH HHS; U54 CA105480-05/CA/NCI NIH HHS; U54-CA105480/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Proportion-corrected scaled voxel models for Japanese children and their application to the numerica...
Next Document:  Potential ability of hematoporphyrin to enhance an optical coherence tomographic image of gastric ca...