Document Detail

In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy.
MedLine Citation:
PMID:  18997265     Owner:  NLM     Status:  MEDLINE    
Structural changes in water molecules are related to physiological, anatomical and pathological properties of tissues. Near infrared (NIR) optical absorption methods are sensitive to water; however, detailed characterization of water in thick tissues is difficult to achieve because subtle spectral shifts can be obscured by multiple light scattering. In the NIR, a water absorption peak is observed around 975 nm. The precise NIR peak's shape and position are highly sensitive to water molecular disposition. We introduce a bound water index (BWI) that quantifies shifts observed in tissue water absorption spectra measured by broadband diffuse optical spectroscopy (DOS). DOS quantitatively measures light absorption and scattering spectra and therefore reveals bound water spectral shifts. BWI as a water state index was validated by comparing broadband DOS to magnetic resonance spectroscopy, diffusion-weighted MRI and conductivity in bound water tissue phantoms. Non-invasive DOS measurements of malignant and normal breast tissues performed in 18 subjects showed a significantly higher fraction of free water in malignant tissues (p < 0.0001) compared to normal tissues. BWI of breast cancer tissues inversely correlated with Nottingham-Bloom-Richardson histopathology scores. These results highlight broadband DOS sensitivity to molecular disposition of water and demonstrate the potential of BWI as a non-invasive in vivo index that correlates with tissue pathology.
S H Chung; A E Cerussi; C Klifa; H M Baek; O Birgul; G Gulsen; S I Merritt; D Hsiang; B J Tromberg
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-11-07
Journal Detail:
Title:  Physics in medicine and biology     Volume:  53     ISSN:  0031-9155     ISO Abbreviation:  Phys Med Biol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-12     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  6713-27     Citation Subset:  IM    
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MeSH Terms
Body Water / chemistry*
Breast / chemistry
Breast Neoplasms / chemistry*,  pathology
Diffusion Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Middle Aged
Phantoms, Imaging
Spectrum Analysis / methods*
Grant Support
P30 CA062203/CA/NCI NIH HHS; P30-CA62203/CA/NCI NIH HHS; P41 RR001192/RR/NCRR NIH HHS; P41 RR001192-29/RR/NCRR NIH HHS; P41-RR01192/RR/NCRR NIH HHS; R33 CA120175/CA/NCI NIH HHS; R33 CA120175-04/CA/NCI NIH HHS; U54 CA105480/CA/NCI NIH HHS; U54 CA105480-05/CA/NCI NIH HHS; U54-CA105480/CA/NCI NIH HHS

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