| In vivo visualization of trophozoites in patients with amoebic colitis by using a newly developed endocytoscope. | |
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MedLine Citation:
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PMID: 20579647 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The endocytoscopy system (ECS) is a new method to provide real-time super-magnifying microscopic imaging in vivo. Routine diagnosis of amebic colitis requires multiple tests that are both time consuming and costly. OBJECTIVE: To determine the feasibility of ECS to directly detect the amebic parasites in vivo. DESIGN: Prospective, single-center, pilot study. SETTING: Tertiary-care university hospital. PATIENTS: This study involved 5 patients who were suspected to have amebic colitis by conventional colonoscopy in our institute. INTERVENTIONS: A super-magnifying ECS with 450 x magnification. MAIN OUTCOME MEASUREMENTS: We compared ECS findings with those of conventional methods-serum antibody tests and histology of colon biopsy specimens. RESULTS: We successfully visualized the amebic trophozoites in all 5 cases. In contrast, 3 specimens had positive results on serology, and 3 had positive histology results on hematoxylin and eosin staining. LIMITATIONS: Pilot study with a limited number of patients. Findings were compared only with serology and histology findings. CONCLUSIONS: ECS would be a useful tool for the prompt diagnosis of amebic colitis via the real-time in vivo visualization of amebic trophozoites. |
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Authors:
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Naoki Hosoe; Taku Kobayashi; Takanori Kanai; Rieko Bessho; Tetsuro Takayama; Nagamu Inoue; Hiroyuki Imaeda; Yasushi Iwao; Seiki Kobayashi; Makio Mukai; Haruhiko Ogata; Toshifumi Hibi |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-06-25 |
Journal Detail:
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Title: Gastrointestinal endoscopy Volume: 72 ISSN: 1097-6779 ISO Abbreviation: Gastrointest. Endosc. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2011-01-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0010505 Medline TA: Gastrointest Endosc Country: United States |
Other Details:
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Languages: eng Pagination: 643-6 Citation Subset: IM |
Copyright Information:
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Copyright 2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Colonoscopes* Diagnosis, Differential Dysentery, Amebic / diagnosis*, pathology Entamoeba histolytica Feasibility Studies Female Humans Image Enhancement / instrumentation* Image Processing, Computer-Assisted / instrumentation* Intestinal Mucosa / pathology Male Middle Aged Pilot Projects Trophozoites* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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