Document Detail


In-vivo visualization of gold loaded cells in mice using x-ray computed tomography.
MedLine Citation:
PMID:  22841913     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The ability to perform cell tracking using x-ray computed tomography combined with gold nanoparticles has been demonstrated recently on ex-vivo samples using different malignant and non-malignant cell lines. Here we proved the concept of the method for in-vivo assessment in a small animal model of malignant brain tumours. The limitations of the method due to radiation dose constraints have been investigated using Monte Carlo simulations. Taking into consideration different x-ray entrance doses and the spatial resolution, the visibility of the cell clusters have been evaluated. The results of the experiments conducted on mice implanted with F98 tumour cells confirmed the prediction of the Monte Carlo calculations. Small clusters of cells exogenously loaded with gold nanoparticles could be visualized using our in-vivo method.
Authors:
Alberto Astolfo; Elisabeth Schültke; Ralf Hendrik Menk; Robert D Kirch; Bernhard H J Juurlink; Christopher Hall; Laura-Adela Harsan; Marco Stebel; Davide Barbetta; Giuliana Tromba; Fulvia Arfelli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-25
Journal Detail:
Title:  Nanomedicine : nanotechnology, biology, and medicine     Volume:  -     ISSN:  1549-9642     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233142     Medline TA:  Nanomedicine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Australian Synchrotron Company Ltd., Clayton, Victoria, Australia; Dipartimento di Fisica, Università di Trieste, Trieste, Italy.
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