| In vivo venous blood T1 measurement using inversion recovery true-FISP in children and adults. | |
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MedLine Citation:
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PMID: 20564586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A time-efficient method is described for in vivo venous blood T(1) measurement using multiphase inversion-recovery-prepared balanced steady-state free precession imaging. Computer simulations and validation experiments using a flow phantom were carried out to demonstrate the accuracy of the proposed method for measuring blood T(1) by taking advantage of the continuous inflow of fresh blood with longitudinal magnetization undisturbed by previous radiofrequency pulses. In vivo measurement of venous blood T(1) in the sagittal sinus was carried out in 26 healthy children and adults aged 7-39 years. The measured venous blood T(1) values decreased with age as a whole (P = 0.006) and were higher in females than males (P = 0.013), matching the expected developmental changes and gender differences in human hematocrit level. The estimated mean blood T(1) values were highly correlated with normal hematocrit levels across age and gender groups (Spearman's r = 0.93, P = 0.008). The longitudinal repeatability of this technique was 4.0% as measured by the within-subject coefficient of variation. The proposed multiphase inversion recovery-prepared balanced steady-state free precession imaging method is a feasible technique for fast (< 1 min) and reliable in vivo venous blood T(1) measurement and may serve as an index of hematocrit level in individual subjects. |
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Authors:
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Wen-Chau Wu; Varsha Jain; Cheng Li; Mariel Giannetta; Hallam Hurt; Felix W Wehrli; Danny J J Wang |
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Publication Detail:
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Type: Journal Article; Research Support, American Recovery and Reinvestment Act; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-02-08 Revised Date: 2012-04-27 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1140-7 Citation Subset: IM |
Affiliation:
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Graduate Institute of Oncology, National Taiwan University, Taipei 100, Taiwan, Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Algorithms* Blood Flow Velocity / physiology Blood Volume / physiology* Blood Volume Determination / methods* Child Female Humans Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Angiography / methods* Male Reproducibility of Results Sensitivity and Specificity Veins / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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DA014129/DA/NIDA NIH HHS; MH080892/MH/NIMH NIH HHS; MH080892-S1/MH/NIMH NIH HHS; P41 RR002305-20S10061/RR/NCRR NIH HHS; P41 RR002305-236856/RR/NCRR NIH HHS; P41 RR002305-246007/RR/NCRR NIH HHS; P41 RR002305-255538/RR/NCRR NIH HHS; R01 MH080892-01A2/MH/NIMH NIH HHS; R01 MH080892-01A2S1/MH/NIMH NIH HHS; R01 MH080892-02/MH/NIMH NIH HHS; R01 MH080892-03/MH/NIMH NIH HHS; R01 MH080892-04/MH/NIMH NIH HHS; RR002305/RR/NCRR NIH HHS |
| Comments/Corrections | |
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