| In vivo validation of longitudinal-circumferential area change ratio to estimate myofiber shortening in the heart. | |
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MedLine Citation:
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PMID: 22345526 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The aim of the present study was to validate area change ratio (%AC) against myofiber shortening (%ë f) in the heart in vivo. %AC is emerging as a mechanical index that may approximate %ë f by incorporating both circumferential and longitudinal shortening. However, the physiological significance of %AC remains unclear. We studied the time course of %AC in the anterior mid-left ventricular wall of normal canine heart in vivo (n=14) during atrial pacing over the entire cardiac cycle using transmurally implanted markers and biplane cineradiography (8 msec/frame). %AC was calculated as the myocardial area change relative to the elemental material area on the circumferential- longitudinal plane at the reference configuration (= end diastole). %AC was compared with %ë f that was determined from the transmural fiber orientation directly measured in the heart tissue. The time course of both %AC and %ë f was determined in the subepicardial, midwall, and subendocardial layers. The time course of %AC and %ë f was significantly different, and the difference was more pronounced towards the endocardium. %AC consistently overestimated %ë f. The timing of the peak %AC was significantly delayed compared to that of the peak %ë f. We conclude that %AC is significantly different from %ë f both in magnitude and timing in vivo. %AC overestimates %ë f, and the overestimation is worse towards the endocardial layers. This may be a potentially important limitation when applying %AC to optimization and responder identification for cardiac resynchronization therapy. |
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Authors:
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H Ashikaga; J Omens |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-15 |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: - ISSN: 1558-2531 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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