Document Detail


In vivo transfer of lipoprotein(a) into human atherosclerotic carotid arterial intima.
MedLine Citation:
PMID:  9157954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to compare the atherogenic potential of lipoprotein(a) [Lp(a)] and LDL by measuring the intimal clearance of these two plasma lipoproteins in the atherosclerotic intima of the human carotid artery in vivo. Autologous 131I-Lp(a) and 125I-LDL were mixed and reinjected intravenously 3 hours before elective surgical removal of the arterial intima in four patients. The intimal clearance of Lp(a) and LDL was 229+/-48 and 405+/-127 nL/cm2 per hour, respectively (paired t test; P=.12). The mass accumulation of Lp(a) (114+/-32 ng/cm2 per hour) was on average one 15th that of LDL (paired t test; P=.06), mainly reflecting a low plasma concentration of Lp(a) compared with LDL in the human subjects studied. In accordance with our previous observation in rabbits, there was a positive association between the intimal clearance of LDL and that of Lp(a) (r=.97, P=.03). Accordingly, high plasma levels of Lp(a) may share with LDL the potential for causing lipid accumulation in the arterial intima in humans.
Authors:
L B Nielsen; M L Grønholdt; T V Schroeder; S Stender; B G Nordestgaard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  17     ISSN:  1079-5642     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-06-12     Completed Date:  1997-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  905-11     Citation Subset:  IM    
Affiliation:
Department of Clinical Biochemistry, Rigshospitalet, Herlev, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Aged
Arteriosclerosis / metabolism*
Carotid Arteries / metabolism*,  pathology
Centrifugation, Density Gradient
Chromatography, Gel
Electrophoresis, Agar Gel
Female
Humans
Iodine Radioisotopes
Lipoprotein(a) / blood,  metabolism*
Lipoproteins, LDL / blood,  metabolism
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Lipoprotein(a); 0/Lipoproteins, LDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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