Document Detail


In-vivo transducer to measure dynamic mitral annular forces.
MedLine Citation:
PMID:  22483226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Limited knowledge exists regarding the forces which act on devices implanted to the heart's mitral valve. Developing a transducer to measure the peak force magnitudes, time rates of change, and relationship with left ventricular pressure will aid in device development. A novel force transducer was developed and implanted in the mitral valve annulus of an ovine subject. In the post-cardioplegic heart, septal-lateral and transverse forces were continuously measured for cardiac cycles reaching a peak left ventricular pressure of 90 mmHg. Each force was seen to increase from ventricular diastole and found to peak at mid-systole. The mean change in septal-lateral and transverse forces throughout the cardiac cycle was 4.4±0.2 N and 1.9±0.1 N respectively. During isovolumetric contraction, the septal-lateral and transverse forces were found to increase at peak rate of 143±8 N/s and 34±9 N/s, respectively. Combined, this study provides the first quantitative assessment of septal-lateral and transverse forces within the contractile mitral annulus. The developed transducer was successful in measuring these forces whose methods may be extended to future studies. Upon additional investigation, these data may contribute to the safer development and evaluation of devices aimed to repair or replace mitral valve function.
Authors:
Andrew W Siefert; Jorge H Jimenez; Dustin S West; Kevin J Koomalsingh; Robert C Gorman; Joseph H Gorman; Ajit P Yoganathan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2012-04-05
Journal Detail:
Title:  Journal of biomechanics     Volume:  45     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-24     Completed Date:  2012-08-22     Revised Date:  2013-09-06    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1514-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 313 Ferst Dr., Atlanta, GA 30332, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Equipment Design
Equipment Failure Analysis
Heart Valve Prosthesis*
Mitral Valve / physiology*,  surgery*
Reproducibility of Results
Sensitivity and Specificity
Sheep
Stress, Mechanical
Transducers*
Grant Support
ID/Acronym/Agency:
FDA1061718//PHS HHS; HL63954/HL/NHLBI NIH HHS; HL73021/HL/NHLBI NIH HHS; R01 HL063954/HL/NHLBI NIH HHS; R01 HL073021/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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