Document Detail

In vivo topical anti-inflammatory and wound healing activities of the fixed oil of Caryocar coriaceum Wittm. seeds.
MedLine Citation:
PMID:  20332017     Owner:  NLM     Status:  MEDLINE    
ETHNOPHARMACOLOGICAL RELEVANCE: Caryocar coriaceum Wittm. (Caryocaraceae), popularly known as pequi, is important source of food and used in the folk medicine as wound healing, anti-inflammatory and for the treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer. AIM OF THE STUDY: To evaluate the effects of fixed oil of Caryocar coriaceum (FOCC) on the topical inflammation and cutaneous wound healing. MATERIALS AND METHODS: FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% on model of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excision model in mice. Skin lesions were evaluated by planimetry and histological analysis. RESULTS: FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%) inhibited the ear edema in 38.01% and 39.20% at time 15 min and 1h, respectively, after induction of inflammation, when compared to the positive control. The topical administration of FOCC ointment 12% showed a significantly reduction of unhealed wound area, with increased percentage of wound contraction (96.54%) on day 7 when compared to the other groups. The results of histological evaluation supported the outcome of excision wound model. CONCLUSION: Caryocar coriaceum inhibits the topical inflammation and accelerate cutaneous wound repair.
Maria Liduína Maia de Oliveira; Diana Célia Sousa Nunes-Pinheiro; Adriana Rocha Tomé; Erika Freitas Mota; Islene Araújo Lima-Verde; Francisco Geraldo de Melo Pinheiro; Cláudio Cabral Campello; Selene Maia de Morais
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-21
Journal Detail:
Title:  Journal of ethnopharmacology     Volume:  129     ISSN:  1872-7573     ISO Abbreviation:  J Ethnopharmacol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-17     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7903310     Medline TA:  J Ethnopharmacol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  214-9     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Faculdade de Veterinária, Universidade Estadual do Ceará (UECE), Campus do Itaperi, Fortaleza, Ceará, Brazil.
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MeSH Terms
Administration, Topical
Anti-Inflammatory Agents / pharmacology,  therapeutic use*
Dose-Response Relationship, Drug
Edema / chemically induced,  drug therapy*
Plant Oils / pharmacology,  therapeutic use*
Skin / drug effects*,  injuries,  pathology
Theales / chemistry*
Wound Healing / drug effects*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Ointments; 0/Plant Oils; 0/Xylenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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