| In vivo tolerance assessment of skin after insertion of subcutaneous and cutaneous microdialysis probes in the rat. | |
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MedLine Citation:
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PMID: 12566825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the study was to evaluate the trauma induced by insertion of the linear microdialysis probe in the subcutaneous and dermal tissue in the rat and to check if the microdialysis probe insertion affects transdermal drug delivery. Non-invasive bioengineering methods (TEWL, Laser Doppler Velocimeter, Chromameter) as well as histology were combined to characterize these effects. The results showed that the dermal and subcutaneous insertion of microdialysis probes did not change skin permeability, blood flow and color, confirming the safety of this technique. The probe depth did not influence the trauma. No significant physical damage after probe insertion was noticed. Thus, the present work validates the use of microdialysis in dermatopharmacokinetics studies after topical or systemic drug delivery. |
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Authors:
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F-X Mathy; A-R Denet; B Vroman; P Clarys; A Barel; R K Verbeeck; V Préat |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Skin pharmacology and applied skin physiology Volume: 16 ISSN: 1422-2868 ISO Abbreviation: Skin Pharmacol. Appl. Skin Physiol. Publication Date: 2003 Jan-Feb |
Date Detail:
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Created Date: 2003-02-04 Completed Date: 2003-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9807277 Medline TA: Skin Pharmacol Appl Skin Physiol Country: Switzerland |
Other Details:
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Languages: eng Pagination: 18-27 Citation Subset: IM |
Copyright Information:
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Copyright 2003 S. Karger AG, Basel |
Affiliation:
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Unité de Pharmacie Galénique, Métabolisme, Nutrition et Toxicologie, Université Catholique de Louvain, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Cutaneous Animals Dermis / blood supply, injuries*, pathology Erythema / etiology, pathology Male Microdialysis / adverse effects*, instrumentation, methods Rats Subcutaneous Tissue / blood supply, injuries*, pathology Time Factors |
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