Document Detail

In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site.
MedLine Citation:
PMID:  21287554     Owner:  NLM     Status:  MEDLINE    
Current paradigms suggest that, despite the heterogeneity of myeloid-derived suppressor cells (MDSC), all Gr-1(+) CD11b(+) cells can exert suppressive function when exposed to inflammatory stimuli. In vitro evaluation shows that MDSC from multiple tissue sites have suppressive activity, and in vivo inhibition of MDSC enhances T-cell function; however, the relative capacity of MDSC present at localized inflammatory sites or in peripheral tissues to suppress T-cell responses in vivo has not been directly evaluated. In the current study, we observed that during a tissue-specific inflammatory response, MDSC inhibition of CD8(+) T-cell proliferation and IFN-γ production was restricted to the inflammatory site. Using a prostate-specific inflammatory model and a heterotopic prostate tumor model, we showed that MDSC from inflammatory sites or from tumor tissue possess immediate capacity to inhibit T-cell function, whereas those isolated from peripheral tissues (spleens and liver) were not suppressive without activation of iNOS by exposure to IFN-γ. These data suggest that MDSC are important regulators of immune responses in the prostate during acute inflammation and the chronic inflammatory setting of tumor growth, and that regulation of T-cell function by MDSC during a localized inflammatory response is restricted in vivo to the site of an ongoing immune response.
Jessica M Haverkamp; Scott A Crist; Bennett D Elzey; Cansu Cimen; Timothy L Ratliff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-02-02
Journal Detail:
Title:  European journal of immunology     Volume:  41     ISSN:  1521-4141     ISO Abbreviation:  Eur. J. Immunol.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-22     Completed Date:  2011-04-12     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  1273201     Medline TA:  Eur J Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  749-59     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Adoptive Transfer
Antigens, CD11b / metabolism
Arginase / genetics
Cell Proliferation
Disease Models, Animal
Immune Tolerance*
Inflammation / genetics,  immunology*,  pathology
Mice, Transgenic
Myeloid Cells / immunology*,  pathology
Nitric Oxide Synthase Type II / genetics
Ovalbumin / genetics,  immunology
Prostatitis / genetics,  immunology,  pathology
RNA, Messenger / genetics,  metabolism
Receptors, Chemokine / metabolism
Recombinant Proteins / genetics,  immunology
T-Lymphocytes / immunology,  pathology
Grant Support
Reg. No./Substance:
0/Antigens, CD11b; 0/Gr-1 protein, mouse; 0/RNA, Messenger; 0/Receptors, Chemokine; 0/Recombinant Proteins; 9006-59-1/Ovalbumin; EC Oxide Synthase Type II; EC protein, mouse; EC protein, mouse; EC

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