Document Detail

In vivo study of the effects of peptide-conjugated near-infrared fluorescent quantum dots on the tumorigenic and lymphatic metastatic capacities of squamous cell carcinoma cell line Tca8113 and U14.
MedLine Citation:
PMID:  20480027     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Quantum dots (QDs) have great potential in non-invasive monitoring and imaging of tumor cells in vivo, but it is unknown if QDs affect their tumorigenesis and metastasis. Here, we applied peptide-conjugated near-infrared fluorescent QDs (NIRF-QDs) to label the squamous cell carcinoma cells Tca8113 and U14. We tested the proliferation and apoptotic capacities of both cells, and the capacity of cervical lymph node metastasis after tumorigenesis in U14 cells'. We find that QDs do not affect the tumor cells' capacities to grow, proliferate, and metastasize. Our study provides critical data to support the application of NIRF-QDs in non-invasive monitoring and imaging of tumor cells in vivo.
Zhi-Gang Li; Kai Yang; Yu-An Cao; Gang Zheng; De-Ping Sun; Cheng Zhao; Jia Yang
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Publication Detail:
Type:  Journal Article     Date:  2010-03-31
Journal Detail:
Title:  International journal of molecular sciences     Volume:  11     ISSN:  1422-0067     ISO Abbreviation:  Int J Mol Sci     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-18     Completed Date:  2010-07-02     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101092791     Medline TA:  Int J Mol Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  1413-22     Citation Subset:  -    
Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Chongqing Medical University, China.
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