Document Detail


In vivo studies on thyroxine and triiodothyronine metabolism in the rat.
MedLine Citation:
PMID:  577327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The reciprocal effects of loading amounts of thyroxine (T4) or triiodothyronine (T3) on the in vivo deiodination of their 125I-labelled isotopes by the rat were studied. It was found that the deiodination of a tracer amount of [125I]T3 as measured by the 24-h urinary 125iodide was significantly decreased after administration of a loading dose of non-radioactive T4. A similar decrease in deiodination of [125I]T3 was observed following the injection of a T3 load. In experiments in which the deiodination of [125I]T4 was assessed, the effects on this of loading doses of non-radioactive T4 or T3 differed; while stable T4 induced a significant decrease in deiodination of [125I]T4, stable T3 was without effect. The data is in agreement with the view that T4 and T3 share tissue deiodinating sites and that in such a system T4 appears to have a stronger avidity for those sites.
Authors:
A A Zaninovich; R Boado; O Degrossi; A J Matty
Related Documents :
11354557 - Free radical changes in rat muscle tissue after exercise.
18528657 - Ultrastructural changes at the myotendinous junction induced by exercise.
25299317 - Correction: chronic aerobic exercise associated to dietary modification improve endothe...
2999547 - Immunoassayable adrenocorticotropin in peripheral organs: concentrations during early d...
8968287 - Copd: using nutrition to prevent respiratory function decline.
3182157 - Effect of exercise on plasma renin substrate.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  85     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-07-18     Completed Date:  1977-07-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  351-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Iodine Radioisotopes
Rats
Thyroxine / metabolism*
Triiodothyronine / metabolism*
Chemical
Reg. No./Substance:
0/Iodine Radioisotopes; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Divergent effects of 6-propylthiouracil on 3,3',5'-triiodothyronine (RT3) serum levels and in man.
Next Document:  Long-term turnover of thyroid iodine in the rat as studied by the isotopic equilibrium method.