Document Detail

In vivo studies on thyroxine and triiodothyronine metabolism in the rat.
MedLine Citation:
PMID:  577327     Owner:  NLM     Status:  MEDLINE    
The reciprocal effects of loading amounts of thyroxine (T4) or triiodothyronine (T3) on the in vivo deiodination of their 125I-labelled isotopes by the rat were studied. It was found that the deiodination of a tracer amount of [125I]T3 as measured by the 24-h urinary 125iodide was significantly decreased after administration of a loading dose of non-radioactive T4. A similar decrease in deiodination of [125I]T3 was observed following the injection of a T3 load. In experiments in which the deiodination of [125I]T4 was assessed, the effects on this of loading doses of non-radioactive T4 or T3 differed; while stable T4 induced a significant decrease in deiodination of [125I]T4, stable T3 was without effect. The data is in agreement with the view that T4 and T3 share tissue deiodinating sites and that in such a system T4 appears to have a stronger avidity for those sites.
A A Zaninovich; R Boado; O Degrossi; A J Matty
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta endocrinologica     Volume:  85     ISSN:  0001-5598     ISO Abbreviation:  Acta Endocrinol.     Publication Date:  1977 Jun 
Date Detail:
Created Date:  1977-07-18     Completed Date:  1977-07-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370312     Medline TA:  Acta Endocrinol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  351-6     Citation Subset:  IM    
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MeSH Terms
Iodine Radioisotopes
Thyroxine / metabolism*
Triiodothyronine / metabolism*
Reg. No./Substance:
0/Iodine Radioisotopes; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine

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