| In vivo studies of Scn5a+/- mice modeling Brugada syndrome demonstrate both conduction and repolarization abnormalities. | |
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MedLine Citation:
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PMID: 20638671 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We investigate the extent to which the electrocardiographic (ECG) properties of intact Scn5a+/- mice reproduce the corresponding clinical Brugada syndrome phenotype and use this model to investigate the role of conduction and repolarization abnormalities in the arrhythmogenic mechanism. METHODS AND RESULTS: The ECGs were obtained from anesthetized wild-type and Scn5a+/- mice, before and after administration of the known pro- and antiarrhythmic agents flecainide and quinidine. The ECG intervals were measured and their dispersions calculated. Scn5a+/- hearts showed ventricular arrhythmias, ST elevation, and conduction disorders including increased QT dispersion, accentuated by flecainide. Quinidine did not cause ventricular arrhythmias but exerted variable effects on ST segments and worsened conduction abnormalities. CONCLUSIONS: The ECG features in an Scn5a+/- mouse establish it as a suitable model for Brugada syndrome and demonstrate abnormal conduction and repolarization phenomena. Altered QT dispersion, taken to indicate increased transmural repolarization gradients, may be useful in clinical risk stratification. |
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Authors:
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Claire A Martin; Yanmin Zhang; Andrew A Grace; Christopher L-H Huang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-17 |
Journal Detail:
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Title: Journal of electrocardiology Volume: 43 ISSN: 1532-8430 ISO Abbreviation: J Electrocardiol Publication Date: 2010 Sep-Oct |
Date Detail:
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Created Date: 2010-08-23 Completed Date: 2011-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 433-9 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Physiological Laboratory, University of Cambridge, Cambridge, United Kingdom. clairemartin@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents / pharmacology Brugada Syndrome / physiopathology* Disease Models, Animal* Electrocardiography* Flecainide / pharmacology Heart Conduction System / physiopathology* Mice Mice, Inbred Strains Phenotype Quinidine / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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//Biotechnology and Biological Sciences Research Council; //British Heart Foundation; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 54143-55-4/Flecainide; 56-54-2/Quinidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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