| In vitro/in vivo studies on a buccal bioadhesive tablet formulation of carbamazepine. | |
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MedLine Citation:
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PMID: 11082839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A buccoadhesive controlled-release system for delivery of carbamazepine (CBZ) was prepared by compression of hydroxypropyl methylcellulose (HPMC) and carbomer, incorporating a penetration enhancer, sodium glycodeoxycholate (GDC). The release behaviour of systems containing CBZ and various amounts of the two polymers with and without GDC was found to be non-Fickian. Formation of an interpolymer complex between HPMC and carbomer was confirmed in acidic medium by turbidity, viscosity and FT-IR measurements. Addition of the drug to the buccoadhesive formulation reduced the adhesion force significantly (p < 0.1). GDC did not have any effect on bioadhesion. Permeability of bovine buccal mucosa to CBZ was determined using Ussing diffusion chambers [1]. In vivo interaction between the tablet and tissue was examined histologically as well as by scoring mucosal irritation. Histological changes observed in the buccal epithelium after 4 h contact with the tablets containing GDC recovered completely within 24 h after removal. No measurable plasma level of CBZ was obtained either in the absence or presence of GDC. |
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Authors:
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G Ikinci; Y Capan; S Senel; E Alaaddinoğlu; T Dalkara; A A Hincal |
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Publication Detail:
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Type: Clinical Trial; In Vitro; Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 55 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2001-01-18 Completed Date: 2001-01-18 Revised Date: 2007-01-29 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: GERMANY |
Other Details:
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Languages: eng Pagination: 762-5 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Technology, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adhesives Adult Animals Anticonvulsants / administration & dosage*, adverse effects, pharmacokinetics Carbamazepine / administration & dosage*, adverse effects, pharmacokinetics Cattle Female Humans Irritants Kinetics Lactose / analogs & derivatives Male Methylcellulose / analogs & derivatives Mouth Mucosa / metabolism* Oxazines Solubility Tablets |
| Chemical | |
Reg. No./Substance:
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0/Adhesives; 0/Anticonvulsants; 0/Irritants; 0/Oxazines; 0/Tablets; 298-46-4/Carbamazepine; 63-42-3/Lactose; 9004-67-5/Methylcellulose; 99705-65-4/MK 458 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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