| In vivo studies on amino acid transmitters in the central auditory system of the guinea pig. | |
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MedLine Citation:
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PMID: 2858838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The extracellular concentrations of endogenous amino acids were measured in vivo in the guinea pig cochlear nucleus during sound stimulation. The purpose was to explore whether certain amino acids might be employed as neurotransmitters by the auditory nerve. A dialysis sampling probe was used to collect a dialysate of the cochlear nucleus. The amino acids were determined fluorometrically after precolumn derivation and high-performance liquid chromatography separation. A short pulse of p-chloromercuryphenylsulfonate (p-CMS) was used to reduce the reuptake of amino acids. The concentration of glutamic and aspartic acid increased twofold to threefold during sound stimulation, while gamma-aminobutyric acid was unaffected. The results support a role for glutamic and/or aspartic acids as neurotransmitters in the auditory nerve. |
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Authors:
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J Jarlstedt; B Karlsson; A Hamberger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery Volume: 93 ISSN: 0194-5998 ISO Abbreviation: Otolaryngol Head Neck Surg Publication Date: 1985 Feb |
Date Detail:
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Created Date: 1985-05-14 Completed Date: 1985-05-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8508176 Medline TA: Otolaryngol Head Neck Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 27-30 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Chloromercuribenzenesulfonate
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pharmacology Acoustic Stimulation Alanine / metabolism Amino Acids / metabolism* Animals Aspartic Acid / metabolism Cochlear Nerve / physiology Glutamates / metabolism Glutamic Acid Glycine / metabolism Guinea Pigs Male Neurotransmitter Agents / physiology* Vestibulocochlear Nerve / physiology* gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Glutamates; 0/Neurotransmitter Agents; 554-77-8/4-Chloromercuribenzenesulfonate; 56-12-2/gamma-Aminobutyric Acid; 56-40-6/Glycine; 56-41-7/Alanine; 56-84-8/Aspartic Acid; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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