Document Detail

In vivo spectroscopy of jaundiced newborn skin reveals more than a bilirubin index.
MedLine Citation:
PMID:  15858963     Owner:  NLM     Status:  MEDLINE    
AIM: The aims of this study were to improve the algorithms for calculating a transcutaneous bilirubin index (TcB), to follow the bilirubin concentrations during phototherapy and to evaluate possible changes in skin optical parameters such as pigmentation and erythema during phototherapy. METHOD: Reflectance measurements were performed on 51 jaundiced newborns, of which 10 were subjected to phototherapy. The measurements were collected with a diode array spectrophotometer with an integrating sphere accessory, and a TcB was calculated from the measured spectra using algorithms based on diffusion theory. The newborns' birthweights were > or = 2000 g and their gestational age was > or = 35.5 wk. They had no substantial illnesses, and no newborns were submitted to the study until their second day. Heel prick blood samples were analysed for total serum bilirubin (Sbr) by the diazo reaction method. Phototherapy equipment was either an overhead lamp or lightbed. RESULTS: Measurements from the forehead gave the best correlation between TcB and Sbr (r = 0.81, p < 0.05). However, during phototherapy no significant correlation between TcB and Sbr was observed. A correlation (r = 0.45, p < 0.05) was found between phototherapy and melanin index obtained from the patients' back. CONCLUSIONS: Reflectance spectroscopy is useful in assessing bilirubin concentrations before phototherapy, and can also reveal changes in skin parameters such as pigmentation occurring as a result of phototherapy.
L Lyngsnes Randeberg; E Bruzell Roll; L T Norvang Nilsen; T Christensen; L O Svaasand
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  94     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-04-29     Completed Date:  2005-06-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  65-71     Citation Subset:  IM    
Department of Electronics and Telecommunications, Norwegian University of Science and Technology, Trondheim, Norway.
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MeSH Terms
Bilirubin / analysis*,  blood
Erythema / etiology,  metabolism
Infant, Newborn
Jaundice, Neonatal / metabolism*,  therapy
Melanins / metabolism
Neonatal Screening / methods
Phototherapy / adverse effects
Skin / metabolism*
Spectrophotometry / methods*
Reg. No./Substance:
0/Melanins; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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