Document Detail


In vivo sodium concentration continuously monitored with fluorescent sensors.
MedLine Citation:
PMID:  21088796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sodium balance is vital to maintaining normal physiological function. Imbalances can occur in a variety of diseases, during certain surgical operations or during rigorous exercise. There is currently no method to continuously monitor sodium concentration in patients who may be susceptible to hyponatremia. Our approach was to design sodium specific fluorescent sensors capable of measuring physiological fluctuations in sodium concentration. The sensors are submicron plasticized polymer particles containing sodium recognition components that are coated with biocompatible poly(ethylene) glycol. Here, the sensors were brought up in saline and placed in the subcutaneous area of the skin of mice by simple injection. The fluorescence was monitored in real time using a whole animal imager to track changes in sodium concentrations. This technology could be used to monitor certain disease states or warn against dangerously low levels of sodium during exercise.
Authors:
J Matthew Dubach; Edward Lim; Ning Zhang; Kevin P Francis; Heather Clark
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Publication Detail:
Type:  Journal Article     Date:  2010-11-19
Journal Detail:
Title:  Integrative biology : quantitative biosciences from nano to macro     Volume:  3     ISSN:  1757-9708     ISO Abbreviation:  Integr Biol (Camb)     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-09     Completed Date:  2011-05-20     Revised Date:  2011-08-22    
Medline Journal Info:
Nlm Unique ID:  101478378     Medline TA:  Integr Biol (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  142-8     Citation Subset:  IM    
Affiliation:
Department of Bioengineering, Northeastern University, 360 Huntington Ave., Boston, MA 02115, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biosensing Techniques / methods*
Hyponatremia / diagnosis,  metabolism*
Mice
Mice, Nude
Microscopy, Fluorescence
Skin / chemistry*,  metabolism
Sodium / analysis*,  metabolism
Chemical
Reg. No./Substance:
7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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