Document Detail

In vivo sodium ((23)Na) imaging of the human kidneys at 7 T: Preliminary results.
MedLine Citation:
PMID:  24081646     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To evaluate the feasibility of in vivo (23)Na imaging of the corticomedullary (23)Na gradient and to measure (23)Na transverse relaxation times (T2*) in human kidneys.
METHODS: In this prospective, IRB-approved study, eight healthy volunteers (4 female, 4 male; mean age 29.4 ± 3.6 years) were examined on a 7-T whole-body MR system using a (23)Na-only spine-array coil. For morphological (23)Na-MRI, a 3D gradient echo (GRE) sequence with a variable echo time scheme (vTE) was used. T2* times were calculated using a multiecho 3D vTE-GRE approach. (23)Na signal-to-noise ratios (SNR) were given on a pixel-by-pixel basis for a 20-mm section from the cortex in the direction of the medulla. T2* maps were calculated by fitting the (23)Na signal decay monoexponentially on a pixel-by-pixel basis, using least squares fit.
RESULTS: Mean corticomedullary (23)Na-SNR increased from the cortex (32.2 ± 5.6) towards the medulla (85.7 ± 16.0). The SNR increase ranged interindividually from 57.2 % to 66.3 %. Mean (23)Na-T2* relaxation times differed statistically significantly (P < 0.001) between the cortex (17.9 ± 0.8 ms) and medulla (20.6 ± 1.0 ms).
CONCLUSION: The aim of this study was to evaluate the feasibility of in vivo (23)Na MRI of the corticomedullary (23)Na gradient and to measure the (23)Na T2* relaxation times of human kidneys at 7 T.
KEY POINTS: • High field MR offers new insights into renal anatomy and physiology. • (23) Na MRI of healthy human kidneys is feasible at ultra-high field. • Renal (23) Na concentration increases from the cortex in the medullary pyramid direction. • In vivo measurements of renal (23) Na-T2* times are demonstrated at 7.0 T.
Stefan Haneder; Vladimir Juras; Henrik J Michaely; Xeni Deligianni; Oliver Bieri; Stefan O Schoenberg; Siegfried Trattnig; Stefan Zbýň
Related Documents :
25012936 - Feasibility of time-resolved mr angiography for detecting recanalization of pulmonary a...
22964446 - Prolonged survival and serial magnetic resonance imaging/magnetic resonance spectroscop...
23957566 - Magnetic resonance imaging for assessment of parametrial tumour spread and regression p...
23760216 - Timing-invariant imaging of collateral vessels in acute ischemic stroke.
8367766 - The relationship of facet tropism to degenerative disc disease.
24919566 - Swift mri enhances detection of breast cancer metastasis to the lung.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-2
Journal Detail:
Title:  European radiology     Volume:  -     ISSN:  1432-1084     ISO Abbreviation:  Eur Radiol     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Low-tube-voltage (80 kVp) CT aortography using 320-row volume CT with adaptive iterative reconstruc...
Next Document:  Urinary stone detection and characterisation with dual-energy CT urography after furosemide intraven...