| In-vivo singlet oxygen dosimetry of clinical 5-aminolevulinic acid photodynamic therapy. | |
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MedLine Citation:
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PMID: 19021376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Photodynamic therapy (PDT) is a viable treatment option for a wide range of applications, including oncology, dermatology, and ophthalmology. Singlet oxygen is believed to play a key role in the efficacy of PDT, and on-line monitoring of singlet oxygen during PDT could provide a methodology to establish and customize the treatment dose clinically. This work is the first report of monitoring singlet oxygen luminescence in vivo in human subjects during PDT, demonstrating the correlation of singlet oxygen levels during PDT with the post-PDT photobiological response. |
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Authors:
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Hans-Joachim Laubach; Sung K Chang; Seonkyung Lee; Imran Rizvi; David Zurakowski; Steven J Davis; Charles R Taylor; Tayyaba Hasan |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of biomedical optics Volume: 13 ISSN: 1083-3668 ISO Abbreviation: J Biomed Opt Publication Date: 2008 Sep-Oct |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-02-27 Revised Date: 2011-03-01 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 050504 Citation Subset: IM |
Affiliation:
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Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, Massachusetts 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminolevulinic Acid
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administration & dosage* Female Humans Luminescent Measurements / methods* Male Photochemotherapy / methods* Photosensitizing Agents / administration & dosage Radiometry / methods* Singlet Oxygen / analysis* Skin / drug effects*, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA84203/CA/NCI NIH HHS; R44 CA096243/CA/NCI NIH HHS; R44 CA096243-02/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Photosensitizing Agents; 106-60-5/Aminolevulinic Acid; 17778-80-2/Singlet Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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