Document Detail


In vivo sampling of cardiac triglyceride from dogs during ethanol infusion.
MedLine Citation:
PMID:  4811215     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The feasibility of procuring and analyzing cardiac tissue for triglyceride in vivo was tested in anesthetized dogs. Measurements of triglycerides in samples obtained in vitro confirmed: reproducibility of triplicate analyses of the glycerideglycerol moiety of tissue triglyceride (SEM +/- 2.1%), homogeneity in and between ventricles (SEM +/- 1.8%), and agreement between right endocardial triglyceride and left myocardial triglyceride (difference not significant). Seven dogs received ethanol, 15-30 mg/kg/min, and five dogs received glucose or 0.85% NaCl for 2 hr. Cardiac output and filling pressure were measured from the left ventricle and tissue was taken from the right ventricle with a biopsy catheter before and during infusions. Three to four samples were obtained from each dog; the average weight was 14.4 mg and two to three biopsies were required for each sample. In the ethanol group, triglyceride increased after 15 min and continued to rise; the final triglyceride concentration correlated with the infusion rate. In the glucose-saline group, in vivo triglyceride concentration did not change and did not differ from postmortem triglyceride. Cardiac function declined in the ethanol group and was unaffected in the controls. Thus, multiple in vivo measurements of cardiac lipid are practical and safe and show that ethanol infusions cause early and progressive accumulation of triglyceride in heart muscle.
Authors:
M Wong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of lipid research     Volume:  15     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1974 Jan 
Date Detail:
Created Date:  1974-03-28     Completed Date:  1974-03-28     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biopsy
Blood Pressure
Cardiac Output / drug effects
Catheterization
Chromatography, Thin Layer
Dogs
Endocardium / drug effects,  metabolism*
Ethanol / pharmacology*
Female
Glucose / pharmacology
Heart / drug effects
Heart Ventricles / metabolism
Kinetics
Male
Myocardium / analysis,  metabolism*
Sodium Chloride / pharmacology
Triglycerides / analysis,  metabolism*
Chemical
Reg. No./Substance:
0/Triglycerides; 50-99-7/Glucose; 64-17-5/Ethanol; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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