Document Detail

In vivo safety of trypan blue use in vitreoretinal surgery.
MedLine Citation:
PMID:  21178657     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study was to evaluate "in vivo" safety of trypan blue (TB) in patients undergoing TB-assisted internal limiting membrane or epiretinal membrane peeling.
METHODS: Prospective study including 21 patients (21 eyes) with full-thickness macular hole and/or epiretinal membrane undergoing TB-assisted internal limiting membrane/epiretinal membrane peeling. Main outcome measures included distance visual acuity, near visual acuity, amplitude of P50 and N95 of the pattern electroretinogram, and fundus autofluorescence; these were assessed preoperatively, at 6 months (n = 21) and 12 months (n = 10) postoperatively.
RESULTS: There was a statistically significant improvement in distance visual acuity, near visual acuity, P50, and N95 amplitude at 6 months and 12 months postoperatively. The mean logarithm of the minimum angle of resolution distance visual acuity and near visual acuity improved from baseline by 0.31 (SD 0.37) and 0.17 (SD 0.31) at 6 months, respectively, and by 0.4 (SD 0.25) and 0.35 (SD 0.28) at 12 months, respectively. The mean P50 and N95 component amplitudes improved by 28% compared with baseline at 6 months (P50 0.4 [SD 0.8]; N95 0.53 [SD 1.07]) and by 63% at 12 months (P50 0.9 [0.85]; N95 1.04 [1.34]). Autofluorescence did not demonstrate damage to the retinal pigment epithelium attributable to TB.
CONCLUSION: No deleterious effects of TB were observed in this study.
Ehab A Abdelkader; Vikki A McBain; Mrinal Anand; Neil W Scott; M A Rehman Siddiqui; Noemi Lois
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  31     ISSN:  1539-2864     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-08-15     Completed Date:  2011-11-15     Revised Date:  2012-10-19    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1122-7     Citation Subset:  IM    
Department of Ophthalmology, Grampian University Hospitals-NHS Trust Aberdeen, Scotland, United Kingdom.
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MeSH Terms
Basement Membrane / pathology
Coloring Agents / adverse effects*,  diagnostic use
Electroretinography / drug effects*
Epiretinal Membrane / diagnosis,  surgery*
Intraoperative Care / methods
Middle Aged
Prospective Studies
Retina / physiology
Retinal Perforations / diagnosis,  surgery*
Trypan Blue / adverse effects*,  diagnostic use
Visual Acuity / drug effects*,  physiology
Vitreoretinal Surgery*
Reg. No./Substance:
0/Coloring Agents; 72-57-1/Trypan Blue
Comment In:
Retina. 2012 Sep;32(8):1691-2; author reply 1692-3   [PMID:  22791175 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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